頁籤選單縮合
| 題 名 | A Semiparametric Approach for the Covariate Specific ROC Curve with Survival Outcome |
|---|---|
| 作 者 | Song, Xiao; Zhou, Xiao-hua; | 書刊名 | Statistica Sinica |
| 卷 期 | 18:3 2008.07[民97.07] |
| 頁 次 | 頁947-965 |
| 分類號 | 319 |
| 關鍵詞 | Location model; Proportional hazards model; Receiver operating characteristic curve; Survival analysis; |
| 語 文 | 英文(English) |
| 英文摘要 | The receiver operating characteristic (ROC) curve has been extended to survival data recently, including the nonparametric approach by Heagerty, Lumley and Pepe (2000) and the semiparametric approach by Heagerty and Zheng (2005) using standard survival analysis techniques based on two different time-dependent ROC curve definitions. However, both approaches do not involve covariates other than the biomarker and cannot be used to estimate the ROC curve adjusted for covariates. To account for the covariate effect, we propose a joint model approach which assumes that the hazard of failure depends on the biomarker and the covariates through a proportional hazards model and that the biomarker depends the covariates through a semiparametric location model. We propose semiparametric estimators for covariate-specific ROC curves corresponding to the two time-dependent ROC curve definitions, respectively. We show that the estimators are consistent and converge to Gaussian processes. In the case of no covariates, the estimators are demonstrated to be more efficient than the Heagerty-Lumley-Pepe estimator and the Heagerty-Zheng estimator via simulation studies. In addition, the estimators can be easily extended to other survival models. We apply these estimators to an HIV dataset. |
本系統中英文摘要資訊取自各篇刊載內容。