頁籤選單縮合
題 名 | Malignant Melanoma: 10 Years Retrospective Study of Buddhist Tzu-chi General Hospital=黑色素細胞癌--慈濟醫院10年回顧及文獻報告 |
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作 者 | 黃裕智; 李俊達; 孫宗伯; 鄭立福; 王健興; 簡守信; | 書刊名 | 中華民國整形外科醫學會雜誌 |
卷 期 | 17:3 2008.09[民97.09] |
頁 次 | 頁240-248 |
分類號 | 415.78 |
關鍵詞 | Malignant melanoma; Acral lentiginous melanoma; Free flap; |
語 文 | 英文(English) |
中文摘要 | 背景:同溯性研究東臺灣黑色素癌。 目標:研究在東臺灣惡性黑色素癌之病人臨床特徵及預後及探討黑色素麣之分類及比例以及接受手術及未接受手術病患存活率之比較。 研究題材及方法:分析在1995年5月到2004年4月36位黑色素麣病患曾在本院治療之臨床表現及預後。 結果:36個病人中,30個病人是屬於ALM,一位屬於NM,一位屬於SSM,對有4位是屬於noncutaneous melanoma。在所有族群中,5年存活率分別為第二期54%,第三期12.5%及第四期0%,28位病患接受外科手術(含淋巴闊創手術)另外8位病患接收保守療法。4位病患同時接受切除手術及治療淋巴廓清手術,另有16位病患在腫瘤切除後再接受淋巴廓清手術,這36位病患的平均存活2.56年(0.024到12年),5年存活率為百分之14(5/36)。這5位病患皆接受外科手術治療,存活率在手術及非手術族群間有顯著差異。 結論:惡性黑色素癌是一個高致命之疾病,早期發現及治療提供較佳之預後,大部分就診的病人在診斷時已較末期之疾病而導致5年存活率下降,雖然在臺灣並不常見,我們強調對大眾及醫師的教育以提供及早的偵測及治療來獲得較佳之預後。 |
英文摘要 | Background: Retrospective review of melanoma in east Taiwan Aim and Objectives: To determine the characteristics and clinical outcome of patients with malignant melanoma in east Taiwan and survey the subtype of melanoma and survival between surgery and non-surgery group Materials and Methods: Thirty-six patients at Buddhist Tzu-Chi Hospital between May 1995 and April 2004 were included into study for clinical features and outcomes. Results: Of the 36 cases, there were 30 cases (84%) of acral lentiginous melanoma (ALM), one (2.7%) of nodular melanoma (NM), one (2.7%) of superficial spreading melanoma (SSM) and 4 cases (11.1%) of noncutaneous melanoma. Twenty-eight patients received surgery with or without lymph node dissection. Eight patients (male: female=7:1) took conservative treatment. Wide excision with therapeutic lymph node dissection was performed on 4 patients. Other sixteen patients received prophylactic LND after definite surgery. There’s no significant difference in survival between surgery and surgery combined with lymph node dissection. The 5-year survival rates of patients with stage II, III, and IV disease were 54%, 12.5%, & o% respectively. The mean survival of the 36 cases was 2.56 years (0.024-12 years). Overall 5-year survival rate was 14% (5/36). All of these 5 patients received surgical excisions. There is significant difference between surgery and non-surgery group. Conclusion: Malignant melanoma is a highly lethal disease. Most of our patient possessed advanced stage at diagnosis and this account for poor 5-year survival in this series. Although uncommon in Taiwan, we strongly emphasize that more education for both general publics and physicians will promote early tumor detection and treatment, providing a better prognosis. (J Plast Surg Asso R.O.C. 2008; 17:240~248) |
本系統中英文摘要資訊取自各篇刊載內容。