頁籤選單縮合
題 名 | Survival of Full-Thickness Skin Graft on the Prelaminated Expanded Polytetrafluoroethylene in Spraque-Dawley Rats=在擴張性四氟乙醯預塑的皮瓣上施行原位性全層皮膚移植存活率的動物性實驗探討 |
---|---|
作 者 | 黃仁吳; 吳思賢; 馬旭; 方榮煌; 沈秉輝; | 書刊名 | 中華民國整形外科醫學會雜誌 |
卷 期 | 17:3 2008.09[民97.09] |
頁 次 | 頁205-215 |
分類號 | 416.413 |
關鍵詞 | Gore-tex; ePTFE; Expanded polytetrafluoroethylene; Skin graft; Tissue engineering; |
語 文 | 英文(English) |
中文摘要 | 本研究的目的在於評估利用植 入生物可相容性的Gore-tex (ePTFE, expanded Polytetrafluoroethlyene)來提供其預塑的皮瓣上施行原位性全層皮膚移植營養的可行性。我們要探討預塑的時間是否為影響全層皮膚存活率的關鍵因子,因此我們設計本實驗來研究,經不同時間的預塑是否會影響預型的皮瓣上施行原位性全層皮膚層移植的存活率;同時測量各組經不同時間預塑的複合移植皮瓣的形變及組織學上的表現,評估是否適合用來做為顏面部重建的複合性皮瓣。以Gore-tex在Spraque-Dawley rats背部做預塑皮瓣,經過二、四及六周的預塑期,之後在預塑複合組織瓣上層植上全層移植皮膚,結果發現移植皮膚的存活率為31%;其中又以Gore-tex預塑四周的存活率最高(35.2%),預塑六周的存活率最低(25.2%)。以預塑的材質相比較,Gore-tex產生變形的情況為縮小成原本的60%;其中又以Gore-tex預塑六周的變形率最高(53.3%),預塑四周的變形率最低(64.6%),且實驗結果顯示Gore-tex不會產生外移或外露的情況。因此用Gore-tex預塑的手術方式無法提供較高的移植皮膚存活率並且會造成變形率,本實驗提供以此複合組織的動物實驗模式,提供臨床應用上的參考。 |
英文摘要 | The purpose of this study is to evaluate and compare the survival and deformity of a full-thickness skin graft over the flap prelaminated by gore-tex (ePTFE, expanded polytetrafluoroethylene, Gore-tex Soft Tissue Patch, Gore & Assoc Inc, Flagstaff, AZ, USA) in Spraque-Dawley (S-D) rats. The material were implanted subcutaneously for prelamination of a 2-, 4-, and 6- week period. A pedicle flap enveloping the implant was then elevated. After applying Biohrane under the composite flap, the harvested full-thickness skin was grafted onto the composite flap. The survival of the FTSG and deformity of synthetic materials were evaluated at the time of one week after skin graft surgery. In this study, the survival of skin graft in the Gore-tex group was about 32%. Microscpically, the Gore-tex scaffold was integrated by fibroneovascular tissue. Based on the survival rate of the skin graft, this study demonstrates that prelamination with Gore-tex can produce a relatively lower survival rate of in-situ skin graft, this study demonstrates that prelamination with Gore-tex can produce a relatively lower survival rate of in-situ skin graft on composite tissue flap, and less implant expulsion was observed. The Gore-tex scaffold allowed growth of fibroneovascular tissue but showed visible deformity. The secondary deformity of the Gore-tex scaffold and lower survival of skin graft neglected the clinical usage of this synthetic flap. (J Plastic Surg Asso R.O.C. 2008; 17:205~215) |
本系統中英文摘要資訊取自各篇刊載內容。