頁籤選單縮合
題 名 | Smad Signal Pathway in BMP-2-induced Osteogenesis--A Mini Review |
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作 者 | Wu, Chiu-jou; Lu, Hsein-kun; | 書刊名 | Journal of Dental Sciences |
卷 期 | 3:1 2008.03[民97.03] |
頁 次 | 頁13-21 |
分類號 | 416.92 |
關鍵詞 | BMP-2; Signal transduction pathway; Smad; Transcription factor; |
語 文 | 英文(English) |
英文摘要 | Bone morphogenetic protein-2 (BMP-2) is a multifunctional growth factor. It strongly induces bone formation and belongs to the transforming growth factor-β (TGF-β) superfamily. Recently, recombinant human BMP-2 (rhBMP-2) and rhBMP-7 (also called osteogenic protein-1; OP-1) has become available for clinical applications. This article focuses on the influence of BMP-2 on intracellular Smad signal transduction pathways of osteoblasts in osteogenesis. After BMP-2 binds to the BMP receptor (BMPR) on cell membranes, the BMPR activates receptor-specific Smads (R-Smads) which then associate with the common-mediator Smad (Co-Smad). This complex is translocated into the nucleus and interacts with several transcription factors such as Runx2/cbfαl, Osx, Dlx5, and Msx2. These molecules mediate the transcription of related genes to induce osteogenesis. |
本系統中英文摘要資訊取自各篇刊載內容。