頁籤選單縮合
題 名 | Sevoflurane as a Pharmacological Probe to Explore the Genesis of the U Wave in the Electrocardiogram |
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作 者 | Luk, Hsiang-ning; Li, Chieh-hung; Chien, Chi-tsung; Lo, Chu-pin; Yuan, Juan-ming; Chiang, Chern-en; | 書刊名 | Journal of Medical and Biological Engineering |
卷 期 | 26:3 民95.09 |
頁 次 | 頁115-120 |
分類號 | 410.1644 |
關鍵詞 | U wave; ECG; Sevoflurane; Volatile anesthetics; |
語 文 | 英文(English) |
英文摘要 | As one of the hypotheses, the presence of after-potentials might contribute to the genesis of U wave in ECG. Volatile anesthetics inhibit cardiac transmembrane ionic currents and intracellular calcium activity. Such pharmacological effects might explain their inhibitory actions on delayed afterdepolarizations and triggered activity. The aim of the present study was to evaluate the possible effect of sevoflurane on U wave in human beings. Perioperative ECG (lead Ⅱ) were recorded and analyzed from 35 gynecologic patients (20 to 70 years old, ASA class Ⅰ). All these 35 patients with sizable U waves were consecutively included in this observational study. Anesthesia was routinely induced with thiamylal, fentanyl and succinyicholine and maintained with sevoflurane and pure 02. U wave amplitude (U(superscript Amp)) was manually measured from amplified ECG records. Discernible U wave in variable size could be identified in 35 patients (58±29 µV). A negative correlation between RR interval and U(subscript Amp) (r=0.471) supported the tachycardia-augmented nature of U wave in the presence of sympathetic stimulation. U(subscript Amp) was larger in extrasystolic beats (350±217% of the control, n-11, p<0.05). Sevoflurane (1 to 1.5 MAC) significantly and reversibly suppressed U(subscript Amp) (a decrease by 53±27 µV, n = 35, p<0.05). The suppressive effect of sevoflurane on U(subscript Amp) might suggest the role of intracellular calcium load and delayed afterdepolarizations as a possible origin of U wave in normal human beings. |
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