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題 名 | The -1131T>C Polymorphism in the Apolipoprotein A5 Gene is Related to Hypertriglyceridemia in Taiwanese Aborigines=脂蛋白元A5 -1131T>C基因多型性與臺灣原住民高三酸甘油酯血症相關 |
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作 者 | 黃孟娟; 王姿乃; 王煥森; 宋宜靜; 葛應欽; 江宏哲; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
卷 期 | 24:4 2008.04[民97.04] |
頁 次 | 頁171-179 |
分類號 | 415.38 |
關鍵詞 | 脂蛋白元A5; 高三酸甘油酯血症; 基因多型性; 臺灣原住民; Apolipoprotein A5; Hypertriglyceridemia; Polymorphism; Taiwanese aborigines; |
語 文 | 英文(English) |
中文摘要 | 台灣原住民具有較高之高三酸甘油血症盛行率,而高三酸甘油脂血症被認為是罹患心血管疾病的獨立危險因子。本研究之目的為探討台灣原住民脂蛋白元 A5 -1131T>C 基因多型性對血清中三酸甘油酯濃度的影響。本研究採橫斷面研究法,針對 316 名無親屬關係的女性台灣原住民,以聚合酶鏈反應-限制性片段長度多型性分析基因型。血清三酸甘油酯濃度 ≥ 150 mg/dL 定義為高三酸甘油酯組,濃度 < 150 mg/dL 則定義為對照組。結果發現,高三酸甘油酯組 C 對偶基因發生頻率為 0.53,此頻率顯著高於對照組 (0.35) (p < 0.001),若與與其他種族民族相比較,台灣原住民 C 對偶基因發生頻率與日本人及漢人相近,但卻高於高加索民族。以多變量邏輯迴歸分析,調整可能的干擾因素後,我們發現與 TT 同型合子相比,帶有 C 對偶基因之基因型,與高三酸甘油酯血症的危險性呈現獨立正相關性 (CT:OR = 3.28、95% CI = 1.43-7.56 ; CC:OR = 5.86、95% CI = 2.15-15.99) (p < 0.01),其中更以 CC 同型合子具有最高之危險性。而該基因的基因多型性也與血清中三酸甘油酯濃度呈現線性的相關性 (p for trend < 0.05)。本研究結果顯示,脂蛋白元 A5 -1131T>C 基因多型性會影響台灣女性原住民血漿中三酸甘油酯的濃度,且 C 對偶基因發生之頻率,在不同種族間亦有差異。 |
英文摘要 | The prevalence of hypertriglyceridemia, considered to be an independent risk factor for the development of cardiovascular disease, is high in Taiwanese aborigines. This study was undertaken to examine the effect of the -1131T>C polymorphism in the apolipoprotein A5 gene on serum triglyceride levels in female Taiwanese aborigines. This was a cross-sectional study, and a total of 316 unrelated female Taiwanese aborigines were genotyped at the -1131T>C polymorphism in apolipoprotein A5 using the polymerase chain reaction-restriction fragment length polymorphism method. Serum triglyceride ≥ 150 mg/dL was defined as the hypertriglyceridemia group and triglyceride < 150 mg/dL was considered to be the control group. The frequency of the minor C allele was significantly higher in the hypertriglyceridemia group (0.53) than in the control group (0.35) (p < 0.001). The frequency of this rare allele was comparable to that in Japanese and Han Chinese, but was higher than that in Caucasians. In a multiple logistic model adjusted for possible confounders, C allele-containing variants were independently associated with greater risks (CT genotype: OR = 3.28, 95% CI = 1.43-7.56; CC genotype: OR = 5.86, 95% CI = 2.15-15.99) of hypertriglyceridemia than the TT genotype (p < 0.01), notably with the CC homozygote exhibiting the greatest risks. The genotype polymorphisms were also associated with serum triglyceride concentrations in a linear fashion (for trend, p < 0.05). Our results indicate that the -1131T>C polymorphism of the Apo A5 gene influences serum triglyceride levels in female Taiwanese aborigines, and that differences exist in the frequency of the C allele among people of various ethnicities. |
本系統中英文摘要資訊取自各篇刊載內容。