頁籤選單縮合
題 名 | Pharmacokinetics and Bioavailability of Caffeic Acid after Oral Administration in Rabbits |
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作 者 | 汪佑襄; 許光陽; | 書刊名 | 中華藥學雜誌 |
卷 期 | 50:4 1998.08[民87.08] |
頁 次 | 頁195-204 |
分類號 | 418.1 |
關鍵詞 | Caffeic acid; Bioavailability; Pharmacokinetics; Double peaks; Flip-flop; Dose-independent; |
語 文 | 英文(English) |
英文摘要 | The pharmacokinetics and bioavailability of caffeic acid (CA) were studied after oral administration in rabbits. Three different doses (5, 10 and 25 mg/kg) of CA solution were orally administered to six rabbits with a one week washout period between each dose. The concentration-time profiles of caffeic acid showed a double peak phenomenon and the elimination phase was obviously different than after intravenous administration, indicating that CA shows "flip-flop" pharmacokinetics. The pharmacokinetic parameters of the CL, CL, CL, and absorption phase half-life showed no signifficant differences for each dose after oral administration. These results indicate that CA exhibits dose-independent pharmacokinetics after oral administration in the dose range of 5 to 25 mg/kg. The results also show that the values of the AUC and C increased linearly with dose in the range of 5 to 25 mg/kg. The absolute bioavailability values of CA were 0.364±0.052, 0.379±0.037 and 0.402±0.087 and the percentages of unchanged CA excreted in the urine were 23.2±4.9, 22.7±3.7 and 22.0±5.3% for doses of 5, 10 and 25 mg/kg, respectively. There were no significant differences in the absolute bioavailability and percentages of unchanged CA excreted in the urine over this dose range. |
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