頁籤選單縮合
題 名 | Studies on the Anti-Psoriatic Activity and Spectroscopy of 10-Benzylthio-Anthralin and its Deuterated Analogs |
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作 者 | 黃旭山; | 書刊名 | 中華藥學雜誌 |
卷 期 | 50:5 1998.10[民87.10] |
頁 次 | 頁267-276 |
分類號 | 418.1 |
關鍵詞 | Anthralin; Anthrone; Psoriasis; Antipsoriatic agents; Inflammatory effect; DEPT experiment; HaCaT cells; Keratinocyte cells; |
語 文 | 英文(English) |
英文摘要 | Antipsoriatic anthrones are among the most commonly used topical agents for the treatment of psoriasis. 10-Arylthio-derivatives of anthralin [dithranol; 1,8-dihydroxy-9(10H)-anthracenone] are of interest in the search for new antipsoriatic agents. The synthesis of 10-benzylthio-1,8-dihydroxy-9(10H)-an-thracenone and its deuterated analogs is described. The application of this information to the design of novel anthrones has resulted in compounds with diminished oxygen radical generating properties which may permit a separation of antipsoriatic and inflammatory effects. The structures of these compounds were confirmed on the basis of �CC NMR and DEPT experiment studies, which also led to the revised assignment of the �禧 NMR spectrum. The compounds were evaluated for their ability to inhibit the growth of the human keratinocyte cell line HaCaT. Biological tests showed that 10-benzylthio-1,8-dihydroxy-9(10H)-an-thracenone slightly inhibited the HaCaT cells. |
本系統中英文摘要資訊取自各篇刊載內容。