頁籤選單縮合
題名 | Nitric Oxide in the Cardiovascular and Pulmonary Circulation--A Brief Review of Literatures and Historical Landmarks |
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作者 | Chen, Hsing I; Chang, Huai-ren; Wu, Chia-yen; Kao, Shang-jyh; Wang, David; Hsieh, Nan-kuang; Hsu, Yung-hsiang; | 書刊名 | 中國生理學雜誌 |
卷期 | 50:2 2007.04[民96.04] |
頁次 | 頁43-50 |
分類號 | 397 |
關鍵詞 | Nitric oxide; Hypertension; Ventricular hypertrophy; Vascular changes; Pulmonary edema; Endothelial factors; |
語文 | 英文(English) |
英文摘要 | Nitric oxide (NO) is an important gas molecule that plays a pivotal role in physiology and pathology in various systems. our laboratory has been working on the hypertensive cardiovascular the role of NO in hypertension, pulmonary disorders, sepsis, and to some extent, the endothelial factors on the arterial baroreceptors and cerebral blood flow. Our studies indicate that the vasodilator effects of endogenous NO act primarily on the small resistance vessels. The large conduit vessels are less affected. In contrast to the earlier work suggesting that No or endothelial function is impaired in hypertension, we have provided evidence to indicate that the No release or function is enhanced in rats with hypertension. Chronic NO deprivation in rats with spontaneous hypertension facilitates the progression of hypertension to malignant phase with marked functional and structural changes in blood vessels of various organs. In most studies using isolated perused lungs, our results show that NO exerts toxic effect on the lung injury following ischemia/reperfusion, air embolism, endotoxemia and hypoxia. Recent clinical investigations have revealed that the inducible No synthase (iNSO) expression was increase in patients with entervirous and other infections suggesting a detrimental role of iNOS and No in the acute lung injury. In this review article, we have also provided the experiences, results and stories in our laboratory during a relatively long period investigating the good and bad sides of NO on the cardiopulmonary functions. The purposes are two-fold: first, to share the experience and stories for scientific and educational purposes; and second, to encourage young investigators to continue work on many questions yet unanswered. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。