頁籤選單縮合
題名 | Prenatal Exposure of Bupropion May Enhance Agitation, Anxiety Responses, and Sensitivity to Cocaine Effects in Adult Mice |
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作者姓名(外文) | Su, Shu-wen; Cherng, G. Chian-fang; Lin, Yin Chiu; Yu, Lung; | 書刊名 | 中國生理學雜誌 |
卷期 | 50:1 2007.02[民96.02] |
頁次 | 頁1-8 |
分類號 | 397 |
關鍵詞 | Prenatal; Stress; Excitability; Sex; Mice; Cocaine; Reward; Sensitization; |
語文 | 英文(English) |
英文摘要 | Major depression and dysthymia afflict a proportion of gravid and breast-feeding women. These women are frequently recommended on antidepressants to relieve their symptoms even if the drug effects on fetal growth and postnatal development are not completely known. In a previous study, we reported that prenatal bupropion exposure seemed to enhance the hedonic value of cocaine in adult mice. This study was undertaken to examine the dose-related effects for prenatal bupropion exposure on the stress susceptibility, cocaine-associated reinforcing property, and cocaine-induced behavioral sensitization in adult mice. Our results showed that various doses (ranging 12.5-50 mg/kg) of prenatal bupropion administration at the third trimester of pregnancy did not affect body weight of the adult mice. Bupropion administration at 50 mg/kg enhanced both ambulatory and rearing responses in the open field test. Moreover, bupropion administration (at 25 and 50 mg/kg) significantly decreased the numbers in open arm entry in the elevateds plus mace test. Furthermore, prenatal bupropion treatment appeared to facilitate the cocaine-induced place preference in a sex-dependent manner. Finally, prenatal bupropion exposure (at 25 and50 mg/kg) accelerated and elevated the development of cocaine-induced sensititzation in locomotor activity. While the antidepressant and smoking-curbing effects of bupropion have been addressed in literature, we suggest that prenatal bupropion exposure could run a risk of enhance individual’s agitation, stress susceptibility and cocaine stimulating propensity in adulthood. |
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