頁籤選單縮合
題名 | A Novel TGD® Device to Generate Therapeutic Platelet Glue |
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作 者 | Tsai, Jui-che; Kuo, Shyh Ming; Chang, Shwu Jen; Manousakas, Ioannis; Chen, Tim-mo; | 書刊名 | Biomedical Engineering: Applications, Basis and Communications |
卷期 | 19:4 2007.08[民96.08] |
頁次 | 頁225-229 |
分類號 | 410.1644 |
關鍵詞 | Thrombin; Platelet glue; Growth factor; TGD® device; |
語文 | 英文(English) |
英文摘要 | The surgical applications of platelet glue (a mixture of platelet gel and fibrin glue) are so far particularly prominent in plastic and orthopedic surgeries. It is shown to accelerate bone fracture and wound healing in many clinical practices. Over the years, one of the components used to prepare platelet glue (PG), thrombin, could only be obtained from pooled human plasma or bovine blood after repeated centrifugation processes. The quantity from this thrombin source is limited and its process deemed time consuming and the risk of infection does exist. Here, we present a stand alone device (TGD®, Thrombin Generation Device) which could prepare large quantities of human thrombin from autologous or single donor allogeneic plasma donations under sterile conditions. With this specific thrombin product, we could easily further mix with platelet and fibrinogen to prepare the platelet glue. PG not only contains various growth factors such as PDGF, TGF-β which are believed to be beneficial to wound healing but also increase the sticky strength in different operations. In this study, the reconstruction efficacy of PG combined with osteoconductive scaffold, biphasic calcium phosphate scaffold, for a post-operative calvarial bone defect was evaluated. |
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