頁籤選單縮合
題 名 | Overexpression of Anion Exchanger 2 in Human Hepatocellular Carcinoma |
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作 者 | Wu, Trang-tiau; Hsieh, Yi-hsien; Wu, Cheng-chung; Tsai, Jen-hsiang; Hsieh, Yih-shou; Huang, Chih-yang; Liu, Jer-yuh; | 書刊名 | 中國生理學雜誌 |
卷 期 | 49:4 民95.08 |
頁 次 | 頁192-198 |
分類號 | 361.8 |
關鍵詞 | DDRT-PCR; Hepatocellular carcinoma; Anion exchanger 2; |
語 文 | 英文(English) |
英文摘要 | To compare gene expression patterns between the poorly-differentiated (HA22T/VGH) and well-differentiated (HepG2) hepatocellular carcinoma cells, messenger RNA was isolated form both kinds of cells and subjected to differential displays reversing transcriptase-polymerase chain reaction (DDRTPCR) technology. Gene fragments showing difference in the expression were recovered, reamplified, cloned and sequenced. Anion exchanger 2 (AE2), an isoform of band 3 protein, was identified and chosen for further characterization. AE2 was strongly expressed in HA22T/VGH cells, while it was little expressed in the well-differentiated hepatocellular carcinoma cells (PLC/PRF5 and HepG2) or little in the normal liver cell (Chang liver). In the 28 pairs of HCC and adjacent non-tumor tissues, levels in the cancer tissue (32.7±5.0) were significantly higher than that in the adjacent non-tumor tissue (9.1±2.4) (P<0.01). Moreover, 19 cases (68%) showed over-expression of AE2 in HCC tissues, 3 cases were similar in both tissues, and 6 cases exhibited little or undetectable signals. Twenty cases (71%) of adjacent normal tissue showed little or undetectable signals. The results indicated that overexpression of AE2 may be involved in the development of human HCC. |
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