頁籤選單縮合
題 名 | Prevalence of Factor V Leiden in the Chinese Population=Leiden第V因子之變異在中國人種中的流行率 |
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作 者 | 何照洪; 周永強; 徐會棋; 高志平; 石佳敏; | 書刊名 | 中華醫學雜誌 |
卷 期 | 62:12 1999.12[民88.12] |
頁 次 | 頁875-878 |
分類號 | 415.142 |
關鍵詞 | 活化C蛋白抗拮性; 中國人人口; Leiden第V因子; 流行率; Activated protein C resistance; Chinese population; Factor V Leiden; Prevalence; |
語 文 | 英文(English) |
中文摘要 | 背景:在大部分國家中,血栓性疾病為導致發病及死亡的主要原因,而Loidon第V因子則為西方國家引起血栓之主因。與西方國家相比,中國人的血栓發生率較低,因此探討中國人是否有Loidon第V因子變異確為必要之課題。 方法:從1997年5月至I998年4月,我們隨意及按次序收集了1,261位不同年齡、性別之中國人(其中420位健康者、719位非血栓性血液疾病患者、77位糖尿病患者及45位深部靜脈血栓症患者),為他們測定Loidon第V因子以瞭解其流行率。研究對象之年齡為1-99歲(平均為50.1 ± 8.3歲),其中873位男性,388位女性。 結果:未有任何研究對象有Loidon第V因子突變(Arg□-Gln突變)。我們隨機測定其中827位之活化C蛋白抗拮性,結果發現他們之活化C蛋白比率均未有<2.0。 結論:中國人並非為帶有Loidon第V因子突變之種族。 |
英文摘要 | Background: Thromboembolic diseases remain a major cause of morbidity and mortality in most countries. Factor V Leiden was found to be a major cause of thromboembolic disease in Western countries. Chinese have proved to be less prone to thromboembolic diseases, therefore investigation of the prevalence of factor V Leiden is necessary among a Chinese population. Methods: From May, 1997, to April, 1998, a total of 1,261 subjects, including 420 healthy subjects, 719 patients with nonthrombotic hematologic disorders, 77 patients with diabetes mellitus and 45 patients with deep vein thrombosis, different in age and sex, were consecutively entered into our study to determine the prevalence of factor V Leiden in the Chinese population (mean age, 50.1 ±18.3 years; range, 1-99 years). Of this population, 873 were male and 388 were female. Results: None of the subjects was found to have factor V Leiden mutation (Arg 506-Gln mutation). Activated protein C resistance was also measured in 827 patients; none of them had an activated protein C ratio of less than 2.0. Conclusions: We suggest that factor V Leiden mutation is rare among the Chinese. |
本系統中英文摘要資訊取自各篇刊載內容。