查詢結果分析
相關文獻
頁籤選單縮合
題 名 | Differences in IL-8 in Serum and Exhaled Breath Condensate from Patients with Exacerbated COPD or Asthma Attacks |
---|---|
作 者 | Liu, Hsu-chung; Lu, Min-chi; Lin, Yi-chun; Wu, Tzu-chin; Hsu, Jeng-yuan; Jan, Ming-shiou; Chen, Chuan-mu; | 書刊名 | Journal of the Formosan Medical Association |
卷 期 | 113:12 2014.12[民103.12] |
頁 次 | 頁908-914 |
分類號 | 415.428 |
關鍵詞 | Asthma; Chronic obstructive pulmonary disease; Cytokines; |
語 文 | 英文(English) |
英文摘要 | Background/Purpose The collection of exhaled breath condensate (EBC) is a noninvasive method that can be used to monitor the inflammatory status of patients with chronic airway diseases. We aimed to study differences in cytokine expression between patients with exacerbations of chronic obstructive pulmonary disease (COPD) and patients with asthma attacks. Methods Using a custom-made device and methods based on American Thoracic Society (ATS)/European Respiratory Society (ERS) recommendations, EBC samples were collected from nine COPD patients, 12 asthma patients and 10 healthy individuals. Cytokine concentrations in serum and EBC were measured via commercial ELISA kits. Results Of four cytokines measured in EBC [interleukin-8 (IL-8), IL-17, IL-4 and tumor necrosis factor-α (TNF-α)], only IL-8 was significantly higher in COPD than in asthma patients (5.27 ± 0.18 vs. 4.36 ± 0.34 pg/mL, p = 0.001). Moreover, COPD patients had higher serum IL-8 than asthma patients (10.57 ± 0.55 vs. 5.15 ± 0.24 pg/mL, p < 0.001). No significant correlation between serum and EBC cytokine concentrations was observed in each subgroup of patients. Conclusion Compared with patients with asthma attacks, patients with exacerbated COPD had increased IL-8 expression in both serum and EBC. These results suggest that IL-8 may be more important in airway and systemic inflammation in COPD exacerbations than in asthma attacks. |
本系統中英文摘要資訊取自各篇刊載內容。