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題 名 | Collagen Synthesis in Idiopathic and Dilantin-Induced Gingival Fibromatosis=原因不明與狄蘭汀引起的齒齦纖維瘤膠原蛋白合成的研究 |
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作 者 | 黃景勝; 何坤炎; 陳慶長; 吳逸民; 王俊欽; 何雅萍; 劉振聲; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
卷 期 | 13:3 1997.03[民86.03] |
頁 次 | 頁141-148 |
分類號 | 416.94 |
關鍵詞 | 狄蘭汀; 齒齦纖維瘤; 膠原蛋白合成; Collagen synthesis; Dilantin; Gingival fibromatosis; |
語 文 | 英文(English) |
中文摘要 | 齒齦纖維瘤是一種齒齦慢性腫大但非出血性的罕見口腔病變,齒齦纖維瘤有兩種型態:一為原因不明性之齒齦纖維瘤,可能與遺傳因子有關;另一為藥物引發之齒齦纖維瘤大多由服用抗癲癇藥物,如phenytoin所引起。本研究之目的乃利用此兩種不同型態之臨床病例,探討其齒齦組織對膠原纖維過度合成之現象及機轉。四位病人中,兩位為不明原因性之齒齦纖維瘤並伴有多毛症,均為男性,(病例1,10歲與病例2,16歲),另兩位為藥物引起之齒齦纖維瘤,都是女性 (病例3,16歲與病例4,11歲)。由增生齒齦及正常齒齦取得的纖維母細胞,分別加以培養,以其膠原蛋白及Prolyl hydroxylase 的值作為研究對象。由細胞培養的結果發現,培養至第二天時,齒齦纖維瘤取得的纖維母細胞其生長速率較健康組織者快。此外,除病例1外的所有病例,其細胞合成膠原纖維的主要酵素prolyl hydroxylase 的含量也較正常高出2-3倍。膠原纖維在細胞內及培養基的增加量,在三個病例中分別為:61%與60%;16%與36%以及21%與80.7%。 |
英文摘要 | Gingival fibromatosis is an uncommon but benign oral disease which causes progressive and non-hemorrhagic enlargement of the gingival. There are two types of gingival fibromatosis: idiopathic gingival fibromatosis (GF), which is of unknown cause and may be associated with hereditary factors, and drug-induced gingival fibromatosis which is caused primarily by phenytoin intake. In cases of gingival fibromatosis, either the teeth are delayed in emergence or most of the crowns are embedded in the soft tissue even after full eruption. The objective of this study was to examine the basis of excess collagen formation in the two types of gingival fibromatosis in four patients admitted to the dental clinic at Kaohsiung Medical College Hospital, Kaohsiung, Taiwan. There were two male patients, aged ten (Case 1) and sixteen (Case 2), with idiopathic gingival fibromatosis and hypertrichosis, and two female patients, aged sixteen (Case 3) and eleven (Case 4), with Dilantin-induced gingival hyperplasia (DGH). Cultures of gingival fibroblasts were established either from clinically excised hyperplastic tissues or from pre-orthodontic surgical normal gingival. The synthesis of collagen and levels of prolyl hydroxylase, a key enzyme in collagen synthesis, were examined in the healthy and affected fibroblasts. Our studies showed that after two days in culture, fibroblasts from all four patients multiplied faster than healthy gingival fibroblasts, though the amount of DNA and protein per cell remained unchanged. In addition, all cultures (except Case 1) had a 2- to 3- fold increase of prolyl hydroxylase activity over that of the controls. As in the cases of prolyl hydroxylase activity, Case 1 did not show any change in collagen synthesis when compared to the control. However, Cases 2, 3, and 4 showed appreciable collagen increases in the cell and medium: 61% and 60% for Case 2; 16% and 36% for Case 3; and 21% and 80.7% for Case 4 respectively. |
本系統中英文摘要資訊取自各篇刊載內容。