頁籤選單縮合
題 名 | Allene-Eneyne Related Cycloaromatization: Design and Synthesis of New DNA-Cleaving Compounds |
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作 者 | 吳明忠; 林志峰; 井寶柱; 張麗娟; 杜采潓; 李芳城; 陳惠亭; | 書刊名 | Journal of the Chinese Chemical Society |
卷 期 | 45:4 1998.08[民87.08] |
頁 次 | 頁475-479 |
分類號 | 340 |
關鍵詞 | (Z)-7-sulfonyl-3-hexen-1,5-diyne; Eneyne-allenesulfone; DNA-cleavage; Antitumor antibiotics; |
語 文 | 英文(English) |
英文摘要 | (Z)-7-Sulfony1-3-hexen-1, 5-diyne containing molecules are stable at room temperature and isomerized to eneyne-allene-sulfones under alkaline conditions. These eneyne-allene-sulfones were not isolable, spontaneously cyclized to form biradical intermediates under mild conditions, and exhibited good DNA-claving and human tumor cell line growth inhibition properties. Further studies indicated that compunds bearing on aromatic ring at C(3) and C(4), such as 25, proved to be more active against those tumor cell lines. Removal of acetylene unit at C(1) and C(2), made the resulting compound less active. A related compound, (Z,Z)-12-(2-tetrahydropyl)oxy-1-phenylsulfonyldodeca-4,8-diene , was synthesized. Upon treatment of triethylamine at refluxing benzene, this compound undergoes double cycloaromatization to form a naphalene adduct, which possesses excellent DNA-cleaving activity. |
本系統中英文摘要資訊取自各篇刊載內容。