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頁籤選單縮合
題名 | Reduction of Dilated Cardiomyopathy of Broiler Chickens Model by Pharmacological Treatments--Pathological Aspects=藥物減輕人工誘導白肉雞DCM之病理方面研究 |
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作者 | 吳得進; 林子恩; 林正盛; | 書刊名 | 臺灣獸醫學雜誌 |
卷期 | 33:1 2007.03[民96.03] |
頁次 | 頁6-13 |
分類號 | 437.23 |
關鍵詞 | 擴張型心肌症; 低溫誘導; 心臟衰竭; 白肉雞; Dilated cardiomyopathy; Cold-exposure; Heart failure; Broiler chicken; |
語文 | 英文(English) |
中文摘要 | 我們曾經報告,用低溫方法可以人工誘導白肉雞右心室擴張型心肌症(DCM)的產生。本研究利用此動物模式,來探究藥物有無減低右心室擴張型心肌症程度之效果。方法:3週齡白肉雞開始設定雞舍溫度,低溫組設定在14-16℃,室溫組設定在20-25℃“每組再細分為四組,即各組每天各投perindopril0.1mg/kg/day, carvedilol1mg/kg/day, furosemide1mg/kg/day或不給葯一共五週。每天紀錄飼料攝取量及觀察症狀和死亡情形。每週紀錄體重,每週作3,4隻雞之心臟超音波檢查以及病理解剖並且作觀察。結果:低溫不給藥組的死亡率最高。心臟重量與體重比率,在低溫用藥組使用perindopril以及carvedilol可以減少,葯物組比不給葯物組低(P<0.05)。右心室璧厚在使用perindopril可以減少。右心室擴張型心肌症之程度在perindopril,carvedilol及furosemide組較輕(p<0.05),但是,室溫組皆無差異。結論:利尿劑,β阻斷劑及ACE抑制劑可以減輕白肉雞右心室擴張型心肌症。低溫人工誘導白肉雞右心室擴張型心肌症的動物模式可以作為心室remodeling的機轉的研究。 |
英文摘要 | To examine the effects of drugs on reduction of DCM in the cold-induced broiler-chicken model. Three-week-old broiler chickens were exposed to cold temperature (14-16℃) for 5 weeks and treated with no drug, perindopril (0.1mg/kg/day), carvedilol (1mg/kg/day), or furosemide (1mg/kg/day). Control chickens were housed at 20-25℃ (room temperature) and assigned to one of the four treatment groups. The heart weight/ body weight ratio was decreased by perindopril and carvedilol and was significantly lower in drug treated versus non-drug treated chickens of the cold-exposure group. RV wall thickness can be reduced by perindopril. The highest cardiac mortality was found in the non-drug treated chickens of the cold-exposure group. Severity of DCM can significantly reduce by the three drugs in cold-exposed chickens. Conclusions: Diuretics, β blockers and angiotensin converting enzyme inhibitors reduce the severity of DCM in the cold-exposure chicken model and can be used to study mechanisms of ventricular remodeling. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。