查詢結果分析
相關文獻
- Multivariate Analysis of Prognostic Determinants for Colorectal Cancer Patients with High Preoperative Serum CEA Levels: Prognostic Value of Postoperative Serum CEA Levels
- Prognostic Value of DNA Ploidy Patterns of Colorectal Adenocarcinoma
- Anastomosis Leakage after Curative Resection for Mid and Low Rectal Cancer: A Poor Prognostic Factor?
- Prognostic Significance of Lymph Node Metastasis in Resected Colorectal Cancer
- 大腸直腸癌之病理分類、分期與預後
- 大腸癌之診斷與治療
- Prognosis of T0 and T1 Colorectal Cancer Following Surgical Resection
- Horizontal Tumor Size Is Inversely Related to Prognosis in Nodal-Positive Stage III Colorectal Cancer
- 大腸直腸癌病患術後存活後預測因子分析
- The Impact of Metastatic Ratio to Retrieved Regional Lymph Nodes on Overall Survival in Patients with Stage III Colorectal Cancer: Focus on Numbers of Lymph Node Retrieved Less than 12
頁籤選單縮合
題名 | Multivariate Analysis of Prognostic Determinants for Colorectal Cancer Patients with High Preoperative Serum CEA Levels: Prognostic Value of Postoperative Serum CEA Levels=高術前血清CEA值大腸直腸癌病人預後因素之多變數分析:術後血清CEA值的預後價值 |
---|---|
作者姓名(中文) | 馬政仁; 謝建勳; 王文明; 蘇育正; 黃哲人; 黃宗人; 王照元; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
卷期 | 22:12 民95.12 |
頁次 | 頁604-609 |
分類號 | 416.245 |
關鍵詞 | 胚胎癌抗原; 大腸直腸癌; 預後; Carcinoembryonic antigen; Colorectal cancer; Prognosis; |
語文 | 英文(English) |
中文摘要 | 高術前的血清 CEA 值廣為眾人所研究並且與大腸直腸癌的病人的預後不佳有關。然而,這些病患經由根治手術後的血清 CEA 值仍有相當的差異,有些病患術後的血清 CEA 值依然偏高,有的則會恢復至正常值範圍內。本研究的目的即在找出術後血清 CEA 值對於高術前血清 CEA 值大腸直腸癌的病人預後的意義。從 2002 年 1 月至 2004 年 12 月,共有 423 位患有大腸直腸癌的病人在我們醫院接受手術治療。這裡面有 181 位的病人 (佔全部42.8%),術前血清 CEA 值有異常偏高的情形。其中 165 位的病人接受了根治性切除手術,而其餘 16 位病人因診斷為第四期疾病,接受姑息手術而被排除在外。吾人同時測量並分析這 165 位病人術前及術後血清 CEA。所有接受根治性切除手術的 165 位病人,根據其術後血清 CEA 值分成二群:術後血清 CEA ≥ 5 ng/mL (80 位) 及術後血清 CEA < 5 ng/mL (85 位)。術後血清 CEA 值和腫瘤的位置 (p = 0.042),淋巴結轉移 (p = 0.009),TNM stage (p = 0.001) 及術後復發 (p = 0.004) 皆有顯著相關。多變數分析更顯示淋巴結轉移及高術後血清 CEA 值 ( ≥ 5 ng/mL) 皆為大腸直腸癌病人根治切除手術的獨立預後因子。高術後血清 CEA 值可被視為高術前血清 CEA 值的大腸直腸癌病人的單一獨立 |
英文摘要 | High preoperative serum carcinoembryonic antigen (CEA) levels have been well investigated and found to be associated with poor prognosis in patients with colorectal cancer (CRC). However, it has been observed that the outcome varies after curative resection, along with postoperative serum CEA levels; some patients continue to have high postoperative serum CEA levels while postoperative CEA levels return to normal in others. The purpose of this study was to determine the prognostic significance of postoperative serum CEA levels in CRC patients with high preoperative serum CEA levels. Between January 2002 and December 2004, 423 CRC patients underwent operation in our hospital; 181 (42.8%) had high preoperative serum CEA levels and were enrolled in this study. Among the 181 patients, 165 patients had curative resection; the remaining 16 had stage IV disease, so they underwent palliative surgery and were subsequently excluded from analysis. Pre- and postoperative serum CEA levels were measured and analyzed. All patients had curative resection and were divided into two groups according to postoperative serum CEA levels: one group comprised patients with postoperative serum CEA ≥ 5 ng/mL (n = 80) and the other group comprised patients with postoperative serum CEA levels < 5 ng/mL (n = 85). Postoperative serum CEA levels were significantly related to location of primary tumors (p = 0.042), lymph node metastases (p =0.009), TNM stage (p = 0.001), and postoperative relapse (p = 0.004). The results of multivariate analysis showed that both lymph node metastases and high postoperative serum CEA levels (≥ 5 ng/mL) were independent prognostic factors for CRC patients after curative resection. Postoperative serum CEA levels can be a single independent prognostic determinant in CRC patients with high preoperative serum CEA levels. Intensive follow-up and adjuvant therapy may be necessary in CRC patients who continue to have high postoperative serum CEA levels even after curative resection. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。