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題 名 | 以常規檢測HbA1c之異常圖形篩檢出糖尿病患者變異型血色素的比率=The Frequency of Detection of Hemoglobin Variants in Diabetic Patients Identified by Abnormal Hemoglobin Chromatograms through Routine Use of an A1c Analyzer Tosoh HLC-723 G5 |
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作 者 | 王玫君; 朱志勳; 李鎮堃; 呂志成; 孫宗和; 孫群欽; 莊明儒; 蔡涵凱; 鄭欣如; 林興中; | 書刊名 | 澄清醫護管理雜誌 |
卷 期 | 4:4 2008.10[民97.10] |
頁 次 | 頁51-58 |
分類號 | 415.668 |
關鍵詞 | 糖化血色素; 變異型血色素; 糖尿病; Glycated hemoglobin; Hemoglobin variants; Diabetes mellitus; |
語 文 | 中文(Chinese) |
中文摘要 | 目的:糖化血色素(HbAlc)是評估長期血糖控制 的重要指標,此外每減少I%HbAlc'可 使因大血管病變引起的糖尿病死亡率降低 25% '並減少18%致命或非致命性突發心 臟病發生率。全世界已發表的變異型血 色素,超過700種,台灣常見的變異型有 Hb-G 、Hb-J、Hb-E、Hb-M、Hb-H...等。 變異型血色素常會影響"HbAlc"的測定 值,臨床上經常是醫生發現血糖與HbAlc 不相符,才發現變異型血色素之存在。如 要在一般常規HbAlc檢測中發現其他變異 型血色素,可使用Ion-exchangeHPLC方 法,並注意HbAlc的圓形變化,有異樣則 要進一步探討是否有變異型血色素的存 在。為了探討變異型血色素在糖尿病怠者 精確之比率,以提供臨床醫生及醫檢同仁 更精確的數據。 方法:我們收集了自民國94年3月至7月本科4239 位糖尿病患者之血液,以本科所使用的機 型TosohHLC723 G5 (為陽離子高壓液相 色層分析法),檢測其糖化血色素。當發 現有異常圓形之HbAlc時,則依據平均色 血球容積(MCV)或平均紅血球血色素量 (MCH)的值及使用毛細管血色素電泳 (PrinceCE550 )做變異型血色素檢定。 結果:使用TosohHLC723 G5其intraassay及 interassay之CV皆小於1 % 0 4239位糖尿 病忠者男女比為1: 1.3'年齡介於1-75歲 (mean=62.6) 'HbAlc值介於0.6札19.7 % (mean=8.2 % )。發現變異型血色素共 的例(其中Hb-J6例、Hb-E lt丹、Hb-F 7 例、Hb-H1例) 。所以本科糖尿病患者之 變異型血色素比率為百分之0.35。 結語:台灣變異型血色素的盛行率小於千分之 一。本科糖尿病忠者之變異型血色素比 率為百分之0.35'高於全體民眾之比率, 而變異型血色素影響"HbA1c "的測定 值是難免的,因此強烈建議操作者要注意 HbA1c圓形變化,希望能由常規之HbAlc 檢驗篩選出變異型血色素,以提供臨床醫 生參考。 |
英文摘要 | Aims: Hemoglobin A1c (HbA1c) is an invaluable tool for monitoring long-term glycemic control. Every 1% reduction in HbA1c will decrease by 25% macrovascular mortalily and by 18% fata1 or norifatal cardiovascular events. However, more than 700 characterized Hb variants have been reported in the world. The variant types that have been found in Taiwan include Hb-G, Hb-J, Hb-E, Hb-M, Hb-H, etc. The presence of an Hb variant may produce afalse HbA1c value. Clinically, an Hb variant is suspected when the HbA1 c result varies substantially from the serum glucose level. An ion exchange HPLC method indicating an abnormal HbA1c level is able to identify the possible existence of an Hb variant. The aim of the present study is to evaluate the occurrence of Hb variants among diabetes patients. Methods: Blood samples from 4239 diabetes patients from the Division of Endocrinology and Metabolism of Kaohsiung veterans General Hospital were collected from March to July 2005. A Tosoh HLC723 G5 (using an ion-exchange HPLC methodology) was used to measurement the patients' HbA1 c. A Prince CE 550 (using a capillary electrophoresis methodology) was used to detect Hb variants when an abnormal HbA1c level wasfound Results: The intra-assay and inter-assay coefficients of variation for the Tosoh HLC723 G5 were below 1%. The mean age ofthe 4239 diabetes patients (male.female ratio of 1 :1.3) was 62.6 years old (range 1-75 years old). The mean HbA1c was 8.2% (range 0.6% to 19.7%). Fifteen patients with Hb variants were detected (Hb-J in 6 patients, Hb-E in 1 patient, Hb-F in 7 patients, Hb-H in 1 patient). The prevalence of Hb variants among these diabetes patients was 0.35%. Conclusion: The prevalence of Hb variants in Taiwan is normally below 0.1 %. The prevalence among diabetic patients visiting the Division of Endocrinology and Metabolism of Kaohsiung veteransGeneral Hospital was 0.35%, which is higher than that reported for Taiwan in general. Therefore, Hb variants among diabetes patients might influence the measurement of HbA1 c and, as a result, any abnormal HbA1 c levels during routine HbA1 c measurement should be evaluatedfurther in order to detect the presence of Hb variants. |
本系統中英文摘要資訊取自各篇刊載內容。