頁籤選單縮合
題名 | Effect of Delta-Opioid Receptor Over-Expression on Cortical Expression of GABA□ Receptor α1-Subunit in Hypoxia |
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作 者 | Feng, Yuan; He, Xiaozhou; Yang, Yilin; Chen, Jingshan; Yin, Kaisheng; Xia, Ying; | 書刊名 | 中國生理學雜誌 |
卷期 | 54:2 2011.04[民100.04] |
頁次 | 頁118-123 |
分類號 | 398.2 |
關鍵詞 | GABA receptor; Delta-opioid receptor; Cortex; Hypoxia; |
語文 | 英文(English) |
英文摘要 | Recent studies show that both delta-opioid receptors (DOR) and GABA receptors play a neuroprotective role in the mature cortex. Since we have observed that DOR over-expression renders the cortex more tolerant to hypoxic stress, we asked whether DOR over-expression affects GABA receptors expression in the cortex under hypoxia. As the first step, we investigated the expression of GABAA receptor α1-subunit (GABAA Rα1, the most abundant α-subunit of GABA receptors in the adult brain) in the mouse cortex with transgenic DOR over-expression after hypoxia. The results showed that GABAA Rα1 expression was lower in the transgenic than wild-type cortex, suggesting that DOR overexpression induces an inhibitory effect on GABAA receptor expression. Hypoxia for 1-3 days significantly increased GABAA Rα1 expression in the wild-type cortex, which may be an adaptive strategy for protecting the cortex against hypoxic stress. Interestingly, such increase was not found in the transgenic cortex with DOR over-expression. This may represent an interactive regulation in the transgenic cortex to efficiently balance energy production and consumption for better adaptation to hypoxic environment. Since DOR over-expression increases cortical tolerance to hypoxia, an increase in GABA receptors expression (an energy-costing process) may not be necessary in the cortex with DOR over-expression. |
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