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題名 | Genetic Polymorphisms of Phase Ⅰ and Phase Ⅱ Xenobiotic Enzymes in Human Papillomavirus Related Lesion and Cancer of the Uterine Cervix=第一階段與第二階段代謝異物酵素基因多形性與子宮頸癌化過程之相關性研究 |
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作者 | 黃詠愷; 謝慧真; 孫建安; 趙壯飛; 黃瑞蘭; 賴鴻政; 朱堂元; | 書刊名 | 慈濟醫學 |
卷期 | 18:4 民95.08 |
頁次 | 頁267-274+328 |
分類號 | 417.2832 |
關鍵詞 | 人類乳突病毒; 子宮頸癌; 肝臟第一階段與第二階段代謝異物酵素基因多形性; HPV; Cervical cancer; Phase Ⅰ and phase Ⅱ xenobiotic enzymes gene polymorphism; |
語文 | 英文(English) |
中文摘要 | 目的:子宮頸癌的危險因子除了人類乳突病毒感染為主要因素外,抽煙與賀爾蒙等外來致癌物以及這些致癌物的代謝物皆可能與子宮頸癌的發生有關。本研究主要探討肝臟第一階段代謝酵素(cytochrome P450 1A1, CYP1A1; cytochrome P450 2E1, CYP2E1與microsomal epoxide hydrolase, mEH)與第二階段代謝酵素(glutathione S-transferase M1, GSTM1)基因多形性與子宮頸癌化生成之關係,除此之外亦評估人類乳突病毒感染是否會影響第一階段與第二階段代謝相關酵?基因多型性與子宮頸癌進展之危險性。材料與方法:本病例對照研究總共收集113個子宮頸侵襲癌(invasive cervical cancer, ICC)與80位低度鱗狀上皮細胞病變(low grade squamous intraepithelial lesion, LSIL)個案,以及一比一之年齡配對對照個案。結果:子宮頸侵襲癌、低度鱗狀上皮細胞病變與對照組中賽類乳突病毒感染率分別為55.0%、83.5%與7.0%。人類乳突病毒感染個案發生子宮頸侵襲癌與低度鱗狀上皮細胞病變之危險性分別為19.5與61.6?(95%信賴區間為6.9-55.3與25.3-147.9)。在調整年齡與人類乳突病毒感染情況後,CYP1A1基因之G/G或G/A基因型對於子宮頸侵襲癌具有顯著保護作用(危險對比值:0.3,95%信賴區間為0.1-0.9);GSTM1之null基因型對子宮頸侵襲癌及低度鱗狀上皮細胞病變具有危險性,分別為non-null基因型之2.5與2.4倍。若將CYPa!a與GSTM1基因多形性估交互作用分析,個案若帶有CYP1A1 A/A基因型與GSTM1 null基因型得子宮頸侵襲癌危險為4.2倍。結論:GSTM1基因多形性為子宮頸癌形成早期之相關因子、而CYP1A1與基因多型性則為癌症形成晚期之相關因子。 |
英文摘要 | Objective: Other than a major role of human papillomavirus (HPV) infection, exposure to cigarette smoke, estrogen and possibly other carcinogens my be related to the development of cancer. The aim of this study was to investigate whether the polymorphism of CYP1A1, CYP2E1, mEH, and GSTM1 contributes to the risk of invasive cervical cancer (ICC) and the low-grade squamous intraepithelial lesions (LSIL) of the uterine cervix. Materials and Methods: In this study, genetic polymorphisms of xenobiotic metabolizingenzymes CYP1A1, CYP2E1, mEH, and GSTM1, as well as the status of HPV infection were determined in 113 cases with invasive cervical cancer (ICC), 80 cases of low grade squamous intraepithelial lesion (LSIL, the early lesion of HPV infection), as well as in 1:1 age-matched control subjects. Results: As expected, subjects with results positive for HPV had significant risks for LSIL and ICC, with OR (95% CI) of 19.6 (6.9-55.3) and 61.1 (25.3-147.9), respectively. In comparison with the A/A genotype, A/G or G/G genotype of the CYP1A1 gene showed a protection for ICC, but not for LSIL, with an OR of 0.3 (95% CI of 0.1-0.9) after adjustment with HPV status. Subjects carrying GSTM1 null genotype were at risk for LSIL (OR=2.5; 95% CI: 1.0-6.3) and ICC (OR:2.1;95% CI: 1.0-6.0) after HPV adjustment. The combination of CYP1A1 A/A and GSTM1 null genotype showed a higher risk for ICC (OR of 4.2, 95% CI of 1.4-12.3; p<0.01). Conclusions: The results of this study suggest there is a significant role for the polymorphism of GSTM1 in early stage and that of CYP1A1 in the invasive stage of cervical carcinogenesis in a Taiwanese population. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。