頁籤選單縮合
題名 | Bone Marrow Stem Cell Therapy for Renal Regeneration after Acute Tubular Necrosis: A Dream or a Reality? |
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作者姓名(外文) | Fang, Te-Chao; Wang, Chih-Hsien; Tsai, Jen-Pi; Hsu, Bang-Gee; | 書刊名 | 慈濟醫學 |
卷期 | 19:3 2007.09[民96.09] |
頁次 | 頁115-126 |
分類號 | 416.273 |
關鍵詞 | Acute tubular necrosis; Bone marrow cells; Hematopoietic stem cells; Mesenchymal stem cells; |
語文 | 英文(English) |
英文摘要 | Bone marrow transplantation and organ transplantation studies suggest that bone marrow cells can differentiate into a variety of non-hematological tissues, including renal cells. The results of a number of experimental animal studies also showed that cell therapy (bone marrow cells (BMCs), hematopietic stem cells (HCSs), mesenchymal stem cells (MSCs)) might have the potential to rescue animals from organ injuries. However, when BMCs or HSCs were injected into rodents subjected t ischemic or toxininduced acute tubular necrosis (ATN), the results with regard to whether they could rescue rodents from ATN were inconsistent. The reasons for the conflicting results of BMC or HSC therapy in ATN are unknown, but may be due to the different types of cells injected, number of cells injected, route of injection, or injury model of acute renal failure. It is known that MSCs can contribute to renal tubular regeneration after ATN, although the exact mechanism, either transdifferentiation or effects paracrine/cytokines, is uncertain. In the future, the most pertinent issue is to determine how MSCs protect the renal tubule form injury, and then to imitate the protective or reparative effect pharmacologically. |
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