查詢結果分析
相關文獻
- DNA Polymorphisms of the Renin-Angiotensin System and Risk of Restenosis after Coronary Balloon Angioplasty
- 鼻中隔多型性腺瘤--病例報告
- Clinical Observations og Erythema Multiforme in Children
- 金線連之品種特性與急毒性研究
- 微衛星DNA與逢機增殖多型性DNA在番椒同種內種原鑑定之利用及比較
- 甜瓜逢機增幅多型性核酸(RAPD)標誌分析及其遺傳特性之研究
- RAPD分子標誌在百慕達草品種鑑別之應用
- 下頜下腺多型性腺瘤中的癌--病例報告
- 常見柴胡中藥材品種之分子鑑定
- RAPD標識在番茄雜交一代雜種種子純度鑑定的應用
第1筆 /總和 1 筆
/ 1 筆
頁籤選單縮合
題名 | DNA Polymorphisms of the Renin-Angiotensin System and Risk of Restenosis after Coronary Balloon Angioplasty=腎素-血管緊縮素系統之DNA多型性對冠狀動脈汽球擴張術後再狹窄之影響 |
---|---|
作者 | 陳國慶; 許寬立; 黃瑞仁; 曾春典; 曾淵如; 江福田; Chen, Kuo-chin; Hsu, Kwan-lih; Hwang, Juey-jen; Tseng, Chuen-den; Tseng, Yung-zu; Chiang, Fu-tien; |
期刊 | Acta Cardiologica Sinica |
出版日期 | 20060600 |
卷期 | 22:2 民95.06 |
頁次 | 頁58-66 |
分類號 | 415.3161 |
語文 | eng |
關鍵詞 | 腎素-血管緊縮素系統; 多型性; 冠狀動脈汽球擴張術; 再狹窄; Renin-angiontensin system; Polymorphism; PTCA; Restenosis; |
中文摘要 | 背景 研究顯示腎素-血管緊縮素系統組成基因的多型性可以調控冠狀動脈汽球擴張術後再狹窄的過程,本研究同時探討此系統中不同階段的八種基因多型性對冠狀動脈汽球擴張術後再狹窄的影響。希望藉此對再狹窄的機轉有更進一步的了解。方法 收集290位接受成功汽球擴張術的病人,若病人在追踪過程中有再次發生心絞痛且非侵襲性檢查顯示心肌缺氧,則接受心導管檢查確定有無再狹窄。再狹窄定義為接受汽球擴張術的部位內徑超過百分之五十狹窄。結果 在八種基因多型性中只有ACE D allele在單變項(D/D 72.5%,D/I 54.4%,I/I 47.5%,p value test for trend<0.01)及多變項中(p value test for trend<0.01)分析對再狹窄有顯著影響。本研究特別發現ACE D allele對再狹窄的效果會受AGT-M174 allele的影響而產生相反的結果(p value to test for the interaction term=0.03)。結論 結果顯示在國人ACE D allele會增加冠狀動脈汽球擴張術後的再狹窄且此效果會受AGT-M174 allele的影響而改變,在後基因體時代,探討基因與基因的交互作用也愈來愈重要。本研究嘗試以此一觀點解釋為何在先前眾多的研究中會有不同的結果。 |
英文摘要 | Background and Purpose: DNA polymorphisms of component genes in RAS were reported to modulate the process of post-PTCA restenosis. This study was designed to assess the influence of eight gene polymorphisms involved at different steps of the renin-angiotensin system (RAS) enzymatic cascade on post-percutaneous transluminal coronary angioplasty (PTCA) restenosis simultaneously. We think systemic analysis of predisposing alleles in RAS will clarify our understanding of mechanisms derived from the conflicting results of previous studies. Methods: This prospective study included 290 Chinese patients who underwent a successful angioplasty procedure and follow-up angiography (mean 42.4±14.5 months) if angina recurred with positive noninvasive stress tests. Restenosis was defined as a more than 50% diameter stenosis at the previously treated vessel site. Results: Among these gene polymorphisms, only ACE D allele was significantly associated with post-PTCA restenosis in univariate (D/D 72.5%, D/I 54.4%, I/I 47.5%, p value test for trend<0.01) and multivariate (p value test for trend<0.01) analysis. One novel finding in our study is that the effect of ACE D allele on restenosis is reversed by AGT-M174 allele (p value to test for the interaction term=0.03). Conclusions: Our results indicate ACE D allele increases the risk of post-PTCA restenosis, and this risk is modified by the coexistence of AGT-M174 allele in Chinese patients. Gene-gene interactions have increasing importance in the post-genome era and may explain contradictory results in previous studies. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。