頁籤選單縮合
題 名 | Understanding the Characteristics of L-Ascorbic Acid-Montmorillonite Nanocomposite: Chemical Structure and Biotoxicity |
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作 者 | Chen, Bor-yann; Lee, Yuan-haun; Lin, Wu-ching; Lin, Feng-huei; Lin, King-fu; | 書刊名 | 醫學工程 |
卷 期 | 18:1 民95.02 |
頁 次 | 頁30-36 |
分類號 | 410.1644 |
關鍵詞 | L-ascorbic acid; LAA; Montmorillonite; Dose-response analysis; Saccharomyces cerevisiae; |
語 文 | 英文(English) |
英文摘要 | Following the previous study to intercalate a 5-fluorouracil (5-FU) into the interlayer spacing of montmorillonite (MMT) for colorectal cancer treatment, we selected a safe and non-pathological microorganism, Saccharomy cerevisiae, as indicator microorganism to proceed risk assessment on MMT for feasibility study. Dose-response analysis from the perspective in toxicology was conducted to reval the toxicity rankings of MMT, L-ascorbic acid (LAA) and montmorillonite-L-ascorbic acid (MMT-LAA) composites. This study also tended to intercalated LAA into MMT, observing chemical-structure stabilities of LAA-MMT composites. According to infrared spectroscopic analysis via FTIR, the lattice-vibration peaks of the distorted tetrahedron of SiO4 for MMT were ranged in 400-1200 cm-1. X-ray diffraction analysis also addressed the layer spacing changes in the MMT lattice with pH changes. The variation in the [001] d-spacing changed from 12.4 to 19.4 A with the increased pH, allowing higher intercalation of viable compounds (e.g., LAA) for controlled-release applications. Compared to MMT, LAA, the lowest toxicity (e.g., EC50=3.77°105 ppm) of the hybrid MMT-LAA also strongly suggested that MMT-LAA composite is safe to be used for further applications. In contrast, the lowest EC0(0.564 ppm)suggested the most sensitive characteristics for MMT-LAA composite to induce the toxic response from no-effect condition. MMT is thus feasible for intercalation of LAA in controlled release to pH changes; particularly, MMT-LAA is considered non-toxic for further applications. |
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