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題名 | 暴露二手菸懷孕婦女尿中1-OHP、2-NAP及可丁寧之濃度特性=Urinary Levels of 1-Hydroxypyrene, 2-Naphthol and Cotinine in Pregnant Women Exposed to Environmental Tobacco Smoke (ETS) |
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作者 | 郭憲文; 劉淑惠; 周思源; | 書刊名 | 中臺灣醫學科學雜誌 |
卷期 | 11:1 民95.03 |
頁次 | 頁28-34 |
分類號 | 411.84 |
關鍵詞 | 1-羥基芘; 2-奈酚; 可丁寧; 二手菸; 懷孕婦女; 1-OHP; 2-NAP; 1-Hydroxypyrene; 2-Naphthol; Cotinine; Environmental tobacco smoke; ETS; Pregnant women; |
語文 | 中文(Chinese) |
中文摘要 | 目的 比較暴露二手菸之懷孕婦女尿中1-羥基芘(1-hydroxypyrene; 1-OHP)、2-奈酚(2-naphthol; 2-NAP)及可丁寧(cotinine)濃度。 方法 收集四所大型醫院產房中124名之生產婦女,以問卷方式得到其人口統計學及生活習慣等基本資料,並收集婦女尿液以高效能液相層析儀遲接螢光偵測器(HPLC-Fluorescence)分析尿液中1-OHP及2-NAP濃度、而尿中之cotinine濃度則用HPLC-photodiol分析。 結果 暴露二手菸懷孕婦女尿中代謝物1-HOP、2-NAP及CONTININE之濃度均較沒有暴露二手菸的婦女為高,除尿中cotinine濃度約高出2.0 mg/g cre.外,其他尿中1-HOP與2-NAP之濃度在兩組不具有統計顯著差異。這三種尿中生物指標濃度皆呈現正相關,1-OHP分別與2-NAP (r=0.14)、cotinine (r=0.09)及2-NAP與cotinine(r=0.12)相關性皆為正向,但均不具有統計顯著性之相關。 結論 暴露二手菸者以其尿中cotinine當作生物指標最明顯,而2-NAP亦可當作二手菸中暴露多環芳香碳氫化合物(PAHs)的尿中生物指標。 |
英文摘要 | Purpose. To determine the urinary levels of 1-hydroxypyrene (1-OHP), 2-naphthol (2-NAP) and cotinine in pregnant women exposed to environmental tobacco smoke (ETS). Methods. One-hundred twenty-four pregnant women from four hospitals were interviewed using a questionnaire. Data obtained included demographic information and life styles. The levels of 1-OHP and 2-NAP in urine specimens from all participants were analyzed by HPLC-Fluorescence; urinary cotinine levels were measured by HPLC-photodiol instrumentation. Results. Urinary levels of 1-OHP, 2-NAP and cotinine in the ETS exposure group were higher than the non-exposure group; only urinary cotinine levels differed significantly between the two groups. Urinary levels of 1-OHP were positively correlated with 2-NAP (r=0.14) and cotinine (r=0.09), and 2-NAP and cotinine (r=0.12); however, no significant correlation was found. Conclusions. Urinary cotinine and 2-NAP levels can be used as biomarkers to measure the exposure to poly aromatic hydrocarbons (PAH) emitted from burning cigarettes. |
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