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題 名 | Hepatitis C Viral Infection in Hemodialysis Patients: Clinical and Molecular Studies=血液透析病患C型肝炎病毒感染之臨床及分子研究 |
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作 者 | 吳義勇; 黃信彰; 吳肖琪; 盧瑞華; 候君正; 楊五常; 李壽東; | 書刊名 | 臺灣腎臟醫學會雜誌 |
卷 期 | 14:1 民89.03 |
頁 次 | 頁12-16+42 |
分類號 | 415.816 |
關鍵詞 | 血液透析病患; C型肝炎; 病毒感染; 肝臟疾病; Hepatitis C; Hemodialysis; bDNA assay; RT-nested PCR; |
語 文 | 英文(English) |
中文摘要 | C型肝炎病毒感染已經成全世界血液透析病患肝臟疾病的重要原因。我們比較126位(平均年齡57.3 ± 15.6歲;68位男性,58位女性)C型肝炎病毒抗體及B型肝炎病毒表面抗原陰性與70位(平均年齡53.9 ± 14.6歲;42位男性,28位女性)C型肝炎病毒抗體陽性及B型肝炎病毒表面抗原陰性血液透析病患的血清氨基丙酸轉化酶(ALT),C型肝炎病毒抗體陽性病患的氨基丙酸轉化酶值比陰性病患為高(20.5 ± 11.7 IU/L vs 13.7 ± 9.21 IU/L,P<0.001)。70位C型肝炎病毒抗體陽性及B型肝炎病毒表面抗原陰性血液透析病患中,30(42.8%)位經由branched DNA signal amplification方法測定血清C型肝炎病毒RNA為陽性,48位(68.5%)經由reverse transcription-nested polymerase chain reaction方法測定血清C型肝炎病毒RNA為陽性。C型肝炎病毒RNA陽性病患較陰性病患之氨基丙酸轉化酶值為高(22.4 ± 12.7 IU/L vs 16.5 ± 7.8 IU/L,P<0.05)。若以氨基丙酸轉化酶為16 IU/L是為正常之上限值,則C型肝炎病毒RNA陽性病患之ALT值較陰性病患低(77.1% vs 45.5%,P<0.01)。C型肝炎病毒抗體陽性同時血清之ALT值大於16 IU/L者,則有較危險之C型肝炎病毒RNA陽性(odds ratio:4.3,95% CI:1.4-13.1,P<0.05)。結論:68.5% C型肝炎病毒抗體陽性之血液透析病患,其血清C型肝炎病毒RNA為陽性。C型肝炎病毒抗體陽性及ALT值>16 IU/L者C型肝炎病毒血症之危險性較高。 |
英文摘要 | Hepatitis C viral (HCV) infection has become an important cause for liver disease in hemodialysis patients worldwide. We compared the serum alanine aminotransferase (ALT) in 126hemodialysis (HD) patients (mean age 57.3 ± 15.6 years;68male, 58 female) with negative serum antibody to HCV (anti-HCV) and hepatitis B surface antigen patients to 70 HD patients (mean age 53.9 ± 14.6 years;42 male, 28 female) with positive anti-HCV and negative hepatitis B surface antigen. Quantitation of serum HCV RNA was measured by a quantitative bNDA singal amplification assay and RT-nested PCR. The patients with positive anti-HCV had higher mean ALT values than those without (20.5 ± 11.7 IU/L vs 13.7 ± 9.21 IU/L,P<0.001). 30 (42.8%) and 48 (68.5%) of 70 patients with positive serum anti-HCV and negative hepatitis B surface antigen were positive for serum HCV-RNA by branched DNA signal amplification (bDNA) assay and reverse transcription-nested polymerase chain reaction (RT-nested PCR), respectively. The mean serum ALT levels were significantly higher in patients with positive serum HCV RNA than negative serum HCV RNA (22.4 ± 12.7 IU/L vs 16.5 ± 7.8 IU/L,P<0.05). If the cutoff point of upper normal level of serum ALT is set at 16 IU/L, there was a significant more patients with elevated ALT level in patients with positive HCV RNA than those with negative serum HCV RNA (77.1% vs 45.5%,P<0.01). The dialysis patients with anti-HCV (+) and serum level of ALT greater than 16 IU/L have a higher risk of positive serum HCV RNA (odds ratio: 4.3, 95% CI:1.4~13.1, p<0.05). In conclusion, 68.5% HD patients with positive anti-HCV had positive serum HCV RNA. Patients with positive anti-HCV and serum ALT greater than 16 IU/L have higher risk of HCV viremia. |
本系統中英文摘要資訊取自各篇刊載內容。