頁籤選單縮合
題 名 | Genetic Changes in Ovarian Cancer |
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作 者 | Ling, Kar-san; Chen, Gin-den; Tsai, Horng-jyh; Lee, Maw-sheng; Wang, Po-hui; Liu, Fu-shing; | 書刊名 | Taiwanese Journal of Obstetrics & Gynecology |
卷 期 | 44:3 民94.09 |
頁 次 | 頁218-231 |
分類號 | 417.25 |
關鍵詞 | Metastasis suppressor gene; Oncogene; Ovarian cancer; Tumor suppressor gene; |
語 文 | 英文(English) |
英文摘要 | Ovarian cancer is among the most lethal of all malignancies in women. While chemotherapy is the preferred treatment modality, chemoresistance severely limits treatment success. Chemoresistance may be multifactorial and related to multiple mechanisms, such as alterations in drug transport, changes in cellular proteins involved in detoxification, altered drug target, changes in DNA repair mechanisms, increases in drug damage tolerance, and genetic changes. Genetic changes appear to be associated directly with the loss of chemosensitivity in ovarian cancer. In this review, we detail the possible genetic changes that occur in ovarian cancer, including activation of specific oncogenes, inactivation of tumor suppressor genes, and downregulation of metastasis suppressor genes. |
本系統中英文摘要資訊取自各篇刊載內容。