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題 名 | 抗鬱劑及情緒平穩劑對大白鼠視網膜上c-AMP濃度之影響=The Effects of Antidepressants and Mood Stabilizers on c-AMP Levels in the Retina of Rats |
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作 者 | 陳正宗; 徐淑婷; 李培聞; 吳國揚; 洪秀貞; | 書刊名 | 臺灣精神醫學 |
卷 期 | 11:2 1997.06[民86.06] |
頁 次 | 頁19-26 |
分類號 | 418.214 |
關鍵詞 | 抗鬱劑; 情緒平穩劑; 視網膜; Antidepressants; Mood stabilizers; c-AMP production; Retina; |
語 文 | 中文(Chinese) |
中文摘要 | 目的:由於憂鬱症患者視網膜對光反應具有特別敏感的現象,因此利用視網膜來探討精神科藥物的機轉已成一種實驗模式,本研究即想探討以動物視網膜之實驗方法與精神科藥物之關係。方法:主要是探討各種不同種類的抗鬱劑,包括imipramine, clomipramine, moclobemide, fluoxetine和trazodone以及情緒平穩劑,包括鋰鹽 (lithium)及carbamazepine 對暗室老鼠視網膜細胞內c-AMP濃度的變化。結果:老鼠視網膜經過上述7種藥物處理經過0,15,30,60及90分鐘,c-AMP含量會逐漸減少,在藥物經15分鐘處理時,抑制的現象就非常明顯,雖然所使用的藥品濃度皆使用 10-6M,但是對c-AMP濃度的抑制效果是moclobemide > imipramine > trazo-done > lithium > clomipramine> carbamazepine = fluoxetine,在 30 分鐘時是 moc-lobemide > imipramine = lithium > trazodone > fluoxetine > clomipramine > carbamazepine,在60分鐘時是moclobemide > imipramine > lithium > trazodone > clomipramine > fluoxetine > carbamazepine, 在 90 分鐘時則呈現lithium > moc-lobemide > imipramine > fluoxetine > trazodone > clomipramine > carbamazine。 由以上結果顯示單胺氧化�t抑制劑 (moclobemide)對c-AMP的抑制效果最快出現而且效果持久,而情緒平穩劑(carbamazepine)對暗室大白鼠視網膜內c-AMP濃度的抑制效果最差。結論:中樞神經對憂鬱症之研究很多,針對動物視網膜與抗鬱或情緒平穩劑之研究值得進一步探討。 |
英文摘要 | Objective: This study prospectively investigated the effects of administration of different psychoactive drugs on c-AMP production in the rat retina. Methods: The retinas were removed retina, incubated at 37 ℃, tested on a different retina, and treated with fixed concentrations (1 μM) of either mood stabilizers (lithium and carbamazepine), tricyclic antidepressants (imipramine and clomipramine), second generation antidepressants (fluoxetine and trazodone) or the selective reversible monoamine uptake inhibitor (moclobemide). The incubation times following treatment were 0, 15, 30, 60 and 90 minutes, respectively. Results: In within group comparisons, the control group and all seven drug treatment groups showed statistically significant differences in the suppression of c-AMP production. The most active suppression occurred within the first 15 minutes in incubation in all treatments. The effects of suppression of c-AMP production at different time points also showed statistically significant differences for each of the seven drugs when compared with control and by between groups comparisons. Conclusion: Differences within the same classes of drugs were also found including: 1) Mood stabilizers: Lithium was more potent in inhibiting c-AMP production than carbamazepine which might partially agonize the dopaminergic system with dcreasing inhibitory effects. 2) Tricyclics: Impipramine and clomipramine appeared to have almost similar mechanisms in the inhibition of c-AMP production. 3) Second generation antidepressants: Fluoxetine showed different inhibitory effects on c-AMP production than trazodone. Trazodone expressed an inhibitory effect which more closely aproximated that of imipramine. 4) Moclobemide (MAOI) appeared to inhibit c-AMP production through a mechanism which was almost completely different from the other drugs. Different effects and possible confouding factors will be discussed. |
本系統中英文摘要資訊取自各篇刊載內容。