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頁籤選單縮合
題名 | Prevalence and Characteristics of the Metabolic Syndrome in Chinese Hypertensive Patients: A Hospital-Based Observation=華人高血壓病患中代謝症候群的盛行率與臨床特徵 |
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作者 | 許智能; 陳雅君; 王宗道; | 書刊名 | Acta Cardiologica Sinica |
卷期 | 21:2 2005.06[民94.06] |
頁次 | 頁89-97 |
分類號 | 415.382 |
關鍵詞 | 高血壓; 胰島素阻抗; 代謝症候群; 尿酸; Hypertension; Insulin resistance; Metabolic syndrome; Uric acid; |
語文 | 英文(English) |
中文摘要 | 背景 高血壓是代謝症候群的主要成份,而胰岛素阻抗是造成代謝症候群之代謝異常的病生理基礎。然而,有些降血壓藥物會影響胰岛素阻抗的程度及昇高病患發生第二型糖尿病的機會。所以,了解高血壓病人和代謝症候群的相關性有其臨床上的重要性。本篇研究的目的即在調查華人高血壓病患中代謝症候群的盛行率和臨床特徵。方法和结果 我们收綠了210位男性和216位女性共426位服用降血壓藥物来控制高血壓的病人,並根據修正後的美國國家膽固醇教育計畫Ⅲ中代謝症候群的诊断標準来做分析。平均年龄是65歲(25-95歲)。代謝症候群的盛行率是47.9%。其中,女性病患的代謝症候群盛行率有较男性高的趨势(52.3% vs 43.3%, p=0.064)。此外,女性的代謝症候群分数也顯著高於男性(2.8±1.2 vs 2.4±1.2, p=0.002)。女性腹部肥胖的比率明顯地比男性高(74.1% vs 50.0%, p<0.001)。高三酸甘油酯,高密度脂蛋白膽固醇過低,及高空腹血糖或治療中之糖尿病的盛行率在兩性中则無顯著差别。不論病患有無代謝症候群,血中肌酸酐,總膽固醇,低密度脂蛋白膽固醇或非高密度脂蛋白膽固醇的濃度,左心室重量和蛋白尿的比例並無不同。女性病患中有代謝症候群者,其血清尿酸濃度较無代謝症候群者高(6.5±2.2 vs 5.6±1.1 mg/dL, p=0.011)。男性病患在血清尿酸濃度上也有類似的差别,但並未達到统計學上的顯著意義(7.1±2.0 vs 6.6±1.7 mg/dL, p=0.187)。结論 代謝症候群在華人高血壓病患中,特别是女性,有很高的盛行率。惟這些觀點仍待大规模的前瞻性臨床研究检驗其正確性。 |
英文摘要 | Background: Hypertension is the key component of the metabolic syndrome (MS). Insulin resistance is regarded as the underlying pathophysiological basis of the clustering metabolic abnormalities associated with the MS. However, some antihypertensive agents may influence the insulin resistant state and the propensity for the development of type 2 diabetes. Therefore, it is clinically important to determine the relationships between hypertension and other features of the MS. In this study, we aimed to investigate the prevalence and characteristics of the MS in Chinese hypertensive patients. Methods and Results: Four-hundred and twenty-six patients, 210 men and 216 women, taking antihypertensive agents to control blood pressure were analyzed according to the modified Adult Treatment Panel Ⅲ criteria for the MS. The mean age was 65 years (25-95 years). The prevalence of the MS was 47.9%. There was a trend toward female predominance in the prevalence of the MS (52.3% vs 43.3%, p=0.064). Moreover, women had a significantly higher MS score (2.8±1.2 vs 2.4±1.2, p=0.002). The prevalence of abdominal obesity was significantly higher in women than in men (74.1% vs 50.0%, p<0.001). The prevalence of high triglycerides, low high-density liporprotein cholesterol (HDL-C), and high fasting blood sugar or treated diabetes was similar in both sexes. There were no differences in serum levels of creatinine, total cholesterol, low-density lipoprotein cholesterol, and non-HDL-C, left ventricular mass, and the rate of proteinuria between patients with and without the MS. In female patients, those with the MS had higher serum uric acid levels than those without the MS (6.5±2.2 vs 5.6±1.1mg/dL, p=0.011). This difference was shown as a trend but not statistically significant in male patients (7.1±2.0 vs 6.6±1.7mg/dL, p=0.187). Conclusions: The MS was highly prevalent in Chinese hypertensive patients, especially in females. However, large-scale prospective studies are needed to verify these viewpoints. |
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