頁籤選單縮合
題 名 | Congenital Malformations Associated with Maternal Diabetes |
---|---|
作 者 | Chen,Chih-ping; | 書刊名 | Taiwanese Journal of Obstetrics & Gynecology |
卷 期 | 44:1 2005.03[民94.03] |
頁 次 | 頁1-7 |
分類號 | 417.132 |
關鍵詞 | Congenital malformations; Diabetes mellitus; Pregnancy; |
語 文 | 英文(English) |
英文摘要 | Maternal diabetes has toxic effects on the development of the embryo and significantly increases the risk of congenital malformations in humans. The incidence of fetal structural defects caused by maternal pregestational diabetes s three-to fourfold higher than that caused by non-diabetic pregnancy. The congenital malformations associated with diabetic pregnancy arise before the seventh gestational week. Diabetic embryopathy can affect any developing organ system, including the central nervous system (CNS) (anencephaly, spina bifida, microcephaly, and holoprosencephaly), skeletal system (caudal regression syndrome, sacral agenesis, and limb defects), renal system (renal agenesis, hydronephrosis, and ureteric abnormalities), cardiovascular system (transposition of the great vessels, ventricular septal defects, atrial septal defects, coarctation of the aorta, cardiomyopathy, and single umbilical artery), and gastrointestinal system (duodenal atresia, anorectal atresia, and small left colon syndrome). Pregnant women with fetuses with diabetic embryopathy may have chronic or unrecognized hyperglycemia and elevated levels of glycerated hemoglobin. This review emphasizes the necessity to consider hyperglycemia-induced teratogenesis during genetic counseling of parents with prenatally detected fetal malformations. Successful preconception counseling for women with diabetes mellitus and metabolic control will reduce birth defects and maternal morbidity. |
本系統中英文摘要資訊取自各篇刊載內容。