頁籤選單縮合
題名 | In Vitro Activities of Nine Current Antibiotics against Culprit Bacteria in Nosocomial Infections in an Institution in Northern Taiwan=北臺灣一醫院九種現今抗生素對院內感染菌株抗菌效力之比較 |
---|---|
作者 | 李細祥; 黃協賢; 史麗珠; 蔡明翰; 謝文斌; Lee, Sai-cheong; Huang, Shie-shian; See, Lai-chu; Tsai, Ming-han; Shieh, Wen-ben; |
期刊 | 長庚醫誌 |
出版日期 | 20111100、20111200 |
卷期 | 34:6 2011.11-12[民100.11-12] |
頁次 | 頁580-589 |
分類號 | 418.281 |
語文 | eng |
關鍵詞 | 抗菌效力; 九種現行抗生素; 院內感染菌株; In-vitro activities; Nine current antibiotics; Nosocomial isolates; |
英文摘要 | Background: In recent years, there has been a rapid worldwide emergence of multidrugresistant (MDR) pathogens, especially in cases of nosocomial infections. This study assesses the in vitro activities of ampicillin/sulbactam, cefpirome, colistin, daptomycin, ertapenem, meropenem, teicoplanin, tigecycline and vancomycin against 208 aerobic bacterial pathogens that caused 197 nosocomial infections in 184 patients. Methods: Antimicrobial susceptibility was evaluated by Etest. Broth dilution method was utilized in tigecycline susceptibility testing. Results: Most (140/208, 67%) of the isolates were facultative Gram-negative bacilli. Of the 31 oxacillin-resistant S. aureus (ORSA) isolates, 16 were susceptible to daptomycin (16/31, 51.6%) according to the breakpoint 1 μg/ml. All 31 ORSA isolates were susceptible to teicoplanin, and vancomycin but MICs of vancomycin for all 31 ORSA isolates were 1 μg/ml. Of the 21 isolates of A. baumannii that were multiple-drug-resistant, 19 isolates (19/21, 90%) were susceptible to colistin and 18 isolates (18/21, 86%) sensitive to tigecycline. Of the 22 isolates of E. coli with extended-spectrum beta-lactamase (ESBL), the most susceptible antimicrobial agent were colistin (20/22, 91%), ertapenem (21/22, 96%), meropenem and tigecycline (22/22, 100%). Of the 11 isolates of P. aeruginosa, 6 isolates were susceptible to colistin (6/11, 55%) and all isolates were susceptible to meropenem (11/11, 100%). Conclusion: For nosocomial infections caused by MDR-Acinetobacter baumannii, colistin and tigecycline are usually susceptible according to the result of this study. For nosocomial infections caused by ORSA, ORSA has reduced susceptibility to vancomycin, teicoplanin and daptomycin. For MDR-P. aeruginosa, further study is needed. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。