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題名 | Hydroxyurea and Splenic Irradiation-Induced Tumor Lysis Syndrome in Chronic Myeloid Leukemia: A Case Report and Review of the Literature=慢性骨髓性白血病使用羥基尿素合併脾臟放射治療引發腫瘤溶解症候群--單一病例報告及文獻回顧 |
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作者姓名(中文) | 陳尚文; 黃文聰; 陳昭勳; 黃偉修; 曹朝榮; 黃于倫; 王毓君; 劉校生; 黃冠誠; | 書刊名 | 中華民國癌症醫學會雜誌 |
卷期 | 20:4 2004.12[民93.12] |
頁次 | 頁9-13 |
分類號 | 415.635 |
關鍵詞 | 慢性骨髓性白血病; 羥基尿素; 脾臟放射治療; 腫瘤溶解症候群; Tumor lysis syndrome; Chronic myeloid leukemia; Hydroxyurea; Splenic irradiation; Checkpoint; |
語文 | 英文(English) |
中文摘要 | 治療慢性期之慢性骨髓性血癌的處置,包括使用羥基尿素(hydroxyurea),甲型干擾素(interferon alpha),異體幹細胞移植,以及酪氨酸激酶受器擷抗劑(STI 571,基利克Gleevec)。然而,對於年紀較大的老年慢性骨髓性血癌患者,採用口服羥基尿素緩解白血球過高所引起的症狀,以及使用脾臟放射治療來減輕脾臟腫大所導致的腹部不適,都是目前仍在採行的治療方式。然而,腫瘤溶解症候群(Tumor lysis syndrome)很少會發生在慢性骨髓性白血病患者的治療過程中,而且肇因羥基尿素合併脾臟放射治療導致腫瘤溶解症候群的病例,回顧文獻資料,先前未曾有過論文提及。而本文我們將論述一位老年慢性白血病患者,接受羥基尿素,別嘌呤醇(allopurinol),點滴灌注,以及脾臟放射治療。經過三天之後,產生急性腫瘤溶解症候群。經過積極的支持性治療,甚至包括血液透析,該病患的狀況終於穩定下來,最後安然出院。 |
英文摘要 | The therapeutic agents for chronic myeloid leukemia (CML) in the chronic phase include hydroxyurea, interferon alpha, allogeneic stem cell transplantation, and tyrosine kinase inhibitor (STI 571, Gleevec). For elderly patients, oral hydroxyurea is suitable for the relief of symptoms caused by hyperleukocytosis, and splenic irradiation would be considered if abdominal discomfort or fullness induced by splenomegaly were present. Tumor lysis syndrome (TLS) is seldom seen in the treatment for CML, and TLS caused by hydroxyurea or splenic irradiation is rarely observed. Herein, we report an elderly CML patient who received treatment with hydroxyurea, allopurinol, hydration, and splenic irradiation. After 3 days, acute TLS developed. Aggressive supportive treatment, even hemodialysis, was performed, after which, the condition stabilized. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。