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題名 | Clinicopathologic Evaluation of Immunohistochemical E-Cadherin Expression in 70 Human Gastric Carcinomas=70例人類胃癌之E-cadherin免疫組織化學染色表現的臨床病理評估 |
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作者 | 劉耀基; 吳鴻昇; 于承平; 俞志誠; 陳正榮; 詹德全; 謝宗保; 許桓銘; | 書刊名 | Journal of Medical Sciences |
卷期 | 24:4 2004.08[民93.08] |
頁次 | 頁179-184 |
分類號 | 415.527 |
關鍵詞 | 胃癌; E-cadherin免疫組織; 化學染色; E-cadherin; Gastric carcinoma; |
語文 | 英文(English) |
英文摘要 | Background: E-cadherin plays a crucial role in cellular adhesion in epithelial tissue. The aim of this study was to investigate the role of E-cadherin in gastric tumorigenesis, cancer invasion and metastasis. Methods: E-cadherin expression was analyzed by immunohistochemistry and correlated with clinicopathological characteristics of 70 patients with gastric carcinoma. Results: Of these cases, 8 tumors (11.4%) revealed a preserved E-cadherin expression similar to that of normal gastric mucosa. Reduced E-cadherin expression was noted in 62 tumors (88.6%), while E-cadherin expression was moderately reduced in 35 tumors, and highly reduced in 27 tumors. The correlation of E-cadherin expression with histologic subtypes revealed a significantly higher frequency of reduced expression in diffuse-type and undifferentiated tumors than in intestinal type and differentiated tumors. In contrast, E-cadherin expression did not correlate with lymph node involvement, peritoneal seeding, or TNM staging and survival, although tumors with liver metastasis had relatively preserved E-cadherin expression. Conclusions: These data indicated that impaired expression of E-cadherin contributed to histogenesis and did not correlate with metastasis and poor survival in patients with gastric carcinoma. |
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