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題 名 | 正常人肝炎和各類癌症患者血清組織多胜冴特異抗原的評估=Comparison of Serum Tissue Polypeptide Specific Antigen Leevels in Normal Individuals and Patient with Hepatitis and Cancers |
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作 者 | 林靖南; 盧納密; 徐淑英; 戴鴻章; 廖永樑; | 書刊名 | 內科學誌 |
卷 期 | 8:1 1997.03[民86.03] |
頁 次 | 頁38-45 |
分類號 | 414.81 |
關鍵詞 | 組織多胜冴特異抗原; 組織多胜冴抗原; 收受者操作特性曲線; Tissue polypeptide specific antigen; TPS; Tissue polypeptide antigen; TPA; Receiver operating characteristic; ROC; |
語 文 | 中文(Chinese) |
中文摘要 | 組織多胜 特異抗原 (tissue polypeptide specific antigen; TPS) 是一種較新的血清腫瘤標記,它能夠有效地反應出腫瘤 生長的活性,它是源自利用單株抗體M3偵測組織多胜太抗原(tissue polypeptide antigen; TPA) 中的主要抗原決定位 (epitope)。TPA 被認為是上皮惡性腫瘤的非特異性腫瘤標記,這些腫瘤包括胃癌、肝癌、結 腸直腸癌、肺癌及泌尿道癌等。在此篇研究中,我們測量健康人,肝炎病人 及各類癌症病人的血清TPS濃度,評估血清TPS在臨床上是否能當作惡性 腫瘤篩檢的單一腫瘤標記。我們收集了106個健康人,28個肝炎病人及148 個各類癌症病人,結果發現在健康人的血清中,TPS 有輕微波動的情形, 而且男性中的濃度高於女性。在肝炎病人及癌症病人血清中TPS 濃度較健 康人有意義地升高(P<0.05)。收受者操作特性 (receiver operating characteristic; ROC)曲線的分析中指出,當門檻值 (cutoff value) 設定為95 U/l時,最能有效地區分出健康人及癌症病人,其敏感性 (sensitivity) 為58.1 %,特異性 (specificity) 為91.5 %。但 是在肝炎病人中,由於有TPS不正常升高的現象,其血清TPS門檻值提高 為325 U/l 較為恰當。相關性分析中指出,TPS與麩胺酸草酸轉胺 (aspartate aminotransferase; AST)有較高的正向相關性 (r=0.5 P<0.0001)。當病人的AST濃度不正常升高時 (≧ 30 U/l),往往伴隨 著TPS濃度的不正常升高 (≧95 U/l)。血清TPS作為腫瘤標記有臨床 上的限制,如搭配其他的腫瘤標記,則更能有效地作為惡性腫瘤的篩檢、診 斷及追蹤。 |
英文摘要 | Tissue polyeptide specific antigen (TPS) is a relatively new serum tumor marker that is derived from the application of monoclonal antibody M3 against the main epitope of tissue polypeptide antigen (TPA). TPA is considered as a nonspecific tumor marker for different types of epithelial neoplasm, which include gastric, hepatic, colorectal, pulmonary, genitourinary and many other carcinomas. In our study, we determine the TPS levels for normal individuals, patients with hepatitis and patients suffering from various forms of malignancy. It is our purpose to evaluate these data in order to determine if it is feasible to use TPS as a simple serum screen test for clinical evaluation of malignancies. We collected 106 cases of normal healthy individuals, 28 patients with hepatitis, and 148 patients with different histologic types of malignant tumors. Results of this study show that in healthy individuals, TPS levels tend to fluctuate and higher values are observed in males than in females. Among cancer-stricken patients, TPS concentrations are significantly higher than those of normal people. Utilizing the Receiver Operating Characteristic (ROC) curve, a cutoff value of 95 U/l is used. This value separates the normal individuals from the cancer patients, but its sensitivity is a dismal 58.1% and specificity 91.5%. Among patients with hepatitis, the cutoff value is raised to 325 U/l because of persistently higher values in this group. Correlation with other biochemical data, particularly aspartate aminotransferase (AST), shows a direct proportional increase of TPS level (≧ 95U/l) as the concentration of AST rises (≧ 30 U/l). In conclusion, this study shows that TPS has its clinical limitations. Its clinical applications as tumor screening, early detection, and follow-up tests, can be achieved only if used in conjunction with other tumor marker panels. |
本系統中英文摘要資訊取自各篇刊載內容。