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頁籤選單縮合
題名 | Self-assembly of Gold Nanoparticles by Hybridization of Two Complementary DNAs=利用互補DNA的雜交反應誘發金奈米粒子自組排列 |
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作者 | 郭文旬; 施勝銘; 楊祥之; 袁亦雲; 林玉娟; Kuo, Wen-hsun; Shih, Sheng-ming; Yang, Shiang-chich; Yuan, Yi-yen; Lin, Yuh-jiuan; |
期刊 | Journal of Medical and Biological Engineering |
出版日期 | 20020900 |
卷期 | 22:3 2002.09[民91.09] |
頁次 | 頁113-116 |
分類號 | 410.1644 |
語文 | eng |
關鍵詞 | 金奈米粒子; 雜交反應; Gold nanoparticles; DNA; Hybridization; |
中文摘要 | 利用檸檬酸鈉還原Au(Ⅲ)離子合成產生的金奈米粒子能和修飾雙硫鍵結的DNA產生共價鍵結。修飾互補DNA的兩種金奈米粒子能藉由DNA的雜交反應產生自組排列現象。這種反應會使金奈米粒子溶液由紅色變為藍色。這個結果顯示具有DNA修飾的金奈米粒子運用在生物感測和DNA探針應用於疾病診斷的潛力。 |
英文摘要 | Gold nanoparticles were synthesized by reducing HAuCl4 with trisodium citrate. These gold nanoparticles could react with disulfide group modified DNAs well. The DNAs modified gold nanoparticles assembled into regular array according to the hybridization of two complementary DNAs linked on gold nanoparticles individually. This reaction caused the color of gold nanoparticle solution changed from red to blue. Thus, this phenomenon showed the potential of DNAs modified gold nanoparticles to be applied in biosensing or as DNA probes for diagnosis. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。