頁籤選單縮合
題 名 | Arecoline Excites the Colonic Smooth Muscle Motility via M[feb0]Receptor in Rabbits |
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作 者 | Xie,Dong-ping; Chen,Lian-bi; Liu,Chuan-yong; Zhang,Chun-ling; Liu,Ke-jing; Wang,Paulus S.; | 書刊名 | 中國生理學雜誌 |
卷 期 | 47:2 2004.06[民93.06] |
頁 次 | 頁89-94 |
分類號 | 346.72 |
關鍵詞 | Arecoline; Colon; Antagonist; Intestinal motility; |
語 文 | 英文(English) |
英文摘要 | Arecoline is an effective component of areca (betel nuts, a Chinese medicine named pinang or binglang). The purpose of this study was to investigate the effect of arecoline on the motility of distal colon in rabbits and its mechanisms involved. Strips of colonic smooth muscle were suspended in organ baths containing Krebs solution, and their isometric contractions were examined. The response of smooth muscle to arecoline in colonic strips was recorded. The effects of atropine, gallamine and l, l-dimethyl-4-diphenylacetoxypiperidiniumiodide (4-DAMP) on arecoline-induced contraction were also observed. Arecoline (1 nM-1 μM) produced a concentration-dependent contraction in both the longitudinal and the circular smooth muscle of rabbit colon. Atropine (10 μM) abolished the arecoline (80 nM)-induced contraction. M3 receptor antagonist, 4-DAMP (0.4 μM), abolished the arecoline (80 nM)-related response, whereas M2 receptor antagonist, gallamine (0.4 μM), did not affect the effect of arecoline. These results suggest that arecoline excites the colonic motility via M3 receptor in rabbits. |
本系統中英文摘要資訊取自各篇刊載內容。