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題名 | Effect of Steroid Solutions on Surface Tension Properties of a Synthetic Surfactant=類固醇溶液對合成性表面張力素的表面張力特性之影響 |
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作者姓名(中文) | 練紹弘; 劉道遠; 喻永生; | 書刊名 | Clinical Neonatology |
卷期 | 14:1 2007.06[民96.06] |
頁次 | 頁6-12 |
分類號 | 417.5 |
關鍵詞 | 類固醇溶液; 合成性表面張力素; 表面張力; Surface tension; Dexamethasone; Betamethasone; Budesonide; Exosurf; |
語文 | 英文(English) |
英文摘要 | Surfactant is a perfect carrier for direct pulmonary delivery of steroids. In order to preserve surfactant properties, steroid interference with surface tension should be carefully evaluated. We evaluated the in vitro effect of dexamethasone (Dexa), budesonide (Bude) and betamethasone (Beta) on the surfactant surface tension lowering properties of a synthetic surfactant. The surface tension properties of synthetic surfactant Exosurf Neonatal (Exo) were evaluated in vitro by a Fisher surface tensiometer at 37℃. Commercially available Dexa, Beta and Bude solutions had lower surface tension (p<0.001) compared with water or normal saline, yet they had higher surface tension compared with Exo (p<0.001). Direct addition of the liquid form of Dexa, Beta and Bude to Exo changed the surface tension in a dose-dependent manner. Within the concentrations of 0.375 and 0.625 mg Dexa/5 ml Exo (0.075 ml to 0.125 ml Dexa/5 ml Exo) there was a dramatic rise in surface tension. Within the concentrations of 1 and 3.4 mg Beta/5 ml Exo (0.25 ml to 0.85 ml/5 ml Exo) a sigmoid rise in surface tension was found. Between the doses of 0.5 to 1.5 mg Bude/5 ml Exo (1 ml to 3 ml Bude/5 ml Exo) a gradual rise in surface tension was found. We concluded that the addition of high concentration steroid solutions might affect the surface tension of Exo. Below the concentration of 0.375 mg Dexa/5 ml Exo, 1 mg Beta/5 ml Exo and 0.5 mg Bude/5 ml Exo the surface tension lowering properties of Exo were not significantly altered. |
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