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題名 | Signal Analysis Techniques for Multi-site Recordings of Somatosensory Evoked Potentials in Free Moving Rats=自由移動大鼠多頻道紀錄體感覺誘發電位之訊號分析技術 |
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作者 | 陳信壅; 陳家進; 潘偉豐; 陳昭燃; | 書刊名 | Journal of Medical and Biological Engineering |
卷期 | 24:1 2004.03[民93.03] |
頁次 | 頁1-8 |
分類號 | 398.2 |
關鍵詞 | 多頻道紀錄; 體感覺誘發電位; 獨立成分分析法; 自由移動大鼠; Multi-site recording; Somatosensory evoked potentials; SEPs; Independent component analysis; ICA; Free moving rat; |
語文 | 英文(English) |
中文摘要 | 多頻道紀錄的技術已經被使用在取得影響資訊處理的廣大叢集神經元的特徵。本研究的目的是評估多頻道紀錄腦部神經元活性的系統,以及利用訊號處理的方法應用於自由移動大鼠之研究。我們將以完成一系列的動物實驗,來印證所提出的紀錄系統與分析方法為適用。首先,將麻醉Wistar公鼠,再將其放在立體定位儀器上,以將電極植入主要感覺皮質區。在實驗過程中,紀錄由刺激老鼠尾巴根部所產生的體感覺誘發電位。多頻道的電訊號則可利用多變數的統計方法,稱為獨立成分分析法,在神經元同時被記錄時,重新探尋訊號來源,而且也能除去在電極和獨立的訊號來源間的部分同時發生之資訊。將被分解出來的訊號,利用腦部電位拓譜圖來表示,以觀察訊號在腦部時空的分布。我們的結果指出獨立成分分析法的演算法,在同時紀錄體感覺誘發電位的實驗中,能夠將電刺激的雜訊與體感覺誘發電位分離出來,而且在這同時紀錄的體感覺誘發電位中,能再分離出明顯的獨立成分。本研究可完成多頻道紀錄腦部細胞外神經科學研究,以探討自由活動的動物行為實驗。 |
英文摘要 | Multi-site recording techniques have been used for characterizing the activities of large populations of neurons involved in brain processing. The aim of this study is to evaluate the multi-site recording technique for brain activities and utilize signal analysis for decomposing the underlying information in a study of free moving rats. In our study, male Wistar rats were first anesthetized and then transferred to a stereotaxic apparatus for the implantation of a multi-wire electrode into the primary somatosensory cortex (SI). During the experiment, sessions of somatosensory evoked potential (SEP), induced by electrical stimulus at rat's tail base, were recorded. Using multi-site recordings, independent component analysis (ICA) was used to remove the electrical stimulus artifacts. The decomposed signals, reconstructed from selected components based on cumulative power spectra, were represented in a topographic form in order to observe the spatiotemporal distribution of the rat's brain. Our results indicated that the application of an ICA can extract the dominant components of SEPs related to drowsy and awake states of somatosensory stimuli on the subject animal. The techniques developed in this study would benefit neuroscience studies of awake, free moving rats while performing neuropsychological task. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。