查詢結果分析
來源資料
相關文獻
- An Overview of the Toxicology of Commonly Used Traditional Chinese Medicine
- 建立Acid Phosphatase酵素分析方法大量篩選天然物之抗癌藥
- Pathogenesis of Neurodegenerative Diseases and the Effect of Natural Products on Nitric Oxide Production Implicating in These Diseases
- 以Colletotrichum acutatum BCRC34607次級代謝物進行植物生長抑制及組成分析
- 苯之毒性
- 本土黑殭菌素對甜菜夜蛾幼蟲之毒效探討
- 重金屬銅對植物之影響
- 蟾酥複方之抗炎鎮痛及急性肝毒性研究
- D型病毒性肝炎
- E型病毒性肝炎
頁籤選單縮合
題 名 | An Overview of the Toxicology of Commonly Used Traditional Chinese Medicine=常用傳統中藥之毒理概觀 |
---|---|
作 者 | 翁祖輝; 康照洲; 汪徽五; 林碧珠; | 書刊名 | 藥物食品分析 |
卷 期 | 5:4 1997.12[民86.12] |
頁 次 | 頁241-263 |
專 輯 | 中藥專輯 |
分類號 | 414.34 |
關鍵詞 | 傳統中藥; 天然物; 毒性; Traditional Chinese medicine; Natural products; Toxicity; |
語 文 | 英文(English) |
中文摘要 | 傳統中藥在許多國家的醫療保健系統中扮演很重要的角色。近幾年中藥及天然物 在新藥研發的潛能又重新被重視,一般認為中藥研發缺乏有系統的藥理、毒理及臨床研究。 最近研究顯示中藥能治療某些西藥無效的疾病﹒但是因為藥效及安全性評估資料之不足,使 得中藥的發展仍然受限制。此短篇概論將綜合整理常用中藥的急性、器官、基因、分析及臨 床毒理資料,希望能成為一份中藥毒理介紹及參考資料。急毒性試驗顯示中藥的半致死劑量 分佈由無毒到超毒等級。中藥毒性標的器官包含肝、腎、腸胃道、神經系統及心臟等。部份 中藥在安姆氏試驗中顯示有致突變性,在細胞基因毒性試驗中有能力增加不按計畫之DNA 合成,微小核生成及染色體異變。化學分析結果顯示有些中藥被農藥、重金屬污染或被添加 西藥。中藥不當的使用及特異體質反應可能造成中藥的不良副作用。因此,完備、有系統的 毒性試驗及詳細的毒理機制研究,將非常有助於中藥藥效、安全性之評估及新藥研發。 |
英文摘要 | Traditional Chinese medicine (TCM) plays an important role in health care systems in many parts of the world. Recently, interest in TCM has revived due to the rediscovery of the potential of TCM and natural products in new drug development. There is a general perception that TCM lacks systematic pharmacological, and clinical studies. The deficiency in efficacy and safety has been a major hindrance to the progress of TCM, despite the success of herbal medicine in treatment of diseases for which the orthodox drugs in western medicine are ineffective. This brief review aims to serve as an introduction and a reference guide to TCM toxicology. The review summarizes the toxicity of some commonly used TCMs in terms of acute, systematic, genetic, analytic, and cli toxicology. Acute toxicity study has shown that herbal medicines and their chemical constituents exhibit LD values ranging from the practically nontoxic to supertoxic categories. Target organs of TCM toxicity include liver, kidney, gastrointestinal tract, nervous, and cardiovascular systems. TCM shows mutagenicity in the Ames test and increases the incidence of unscheduled DNA synthesis, micronucleus formation, and chromosomal aberration in cytogenetic assays. Some TCM products are contaminated with pesticides and heavy metals and adulterated with drugs of western medicine. Improper dispensing and use of TCM and individual idiosyncracy may result in adverse effects and fatality. Future TCM research, new drug development, and safety evaluation require adequate toxicity testing and mechanistic toxicology studies.nical oxicology studies. |
本系統中英文摘要資訊取自各篇刊載內容。