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題名 | 保胎湯對「腎虛黃體抑制動物流產模型」之作用評估=Assessment of BaoTai Decoction on an Animal Model of Absorption due to Functional Kidney Deficiency and Luteal Phase Inadequacy |
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作者 | 陳俊明; 馬紅霞; 黃柏憲; 陳立中; 歐陽惠卿; | 書刊名 | 臺灣中醫醫學雜誌 |
卷期 | 3:1 2004.03[民93.03] |
頁次 | 頁5-13 |
分類號 | 414.5 |
關鍵詞 | 自然性流產; 腎虛; 黃體酮; 保胎湯; 疾病模型; Spontaneous miscarriage; Functional kidney deficiency; Progesterone; BaoTai decoction; Disease model; |
語文 | 中文(Chinese) |
中文摘要 | 從黃體功能不全角度探討中藥保胎方防治自然流產的機理。方法:用羥基月尿和米非司建立腎止黃體抑制病證結合動物流產模型的基礎上,設立中藥、黃體酮、腎虛、黃體抑制、病證結合及正常妊娠六組,檢測實驗大鼠體重、黃體酮及其受體的變化,觀察妊娠大鼠胚胎吸收率的情況。結果:(1)用羥基月尿和米非司酮能類比腎虛黃體抑制所致自然流產的狀態;(2)保胎方能促進枉娠大鼠黃體酮的分泌,並使子宮內膜黃體酮受體表達增加,提示該藥在激素及激素受體水平促進黃體功能。 |
英文摘要 | Objective: Too study the mechanism of Chinese traditional medicine protecting and curing spontaneous abortion from corpus luteum insufficiency angle. Methods: On the base of using hydroxyl urine and mifepristone to establish the illness-syndrome incorporation abortion model of kidney deficit and corpus luteum restrainment, we set up Chinese traditional medicine, progesterone, deficiency of the kidney, corpus luteum restrain, illness-syndrome incorporation abortion model and normal gestation six groups, detect the express of progestin and its receptor in experiment white rat and observe gestation white rat embryo abosorptivity. Results: (1)using hydroxyl urine and mifepristone can simulate the spontaneous abortion state caused by deficiency of the kidney and corpus luteum restrain; (2)BâoTaī Decoction can promote progestin’ secretion and inhibit the binding of RU486 to progesterone receptor. It is suggested that BâoTaī Decoction could improve corpus luteum function. |
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