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題 名 | Monitoring of the Levodopa Concentration-Response Relationship in Parkinson's Disease=巴金森氏病患者血中左多巴濃度之監測與藥效反應之關係 |
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作 者 | 吳瑞美; 戴春暉; 陳榮基; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
卷 期 | 16:3 2000.03[民89.03] |
頁 次 | 頁117-125 |
分類號 | 415.83 |
關鍵詞 | 血液; 巴金森氏病; 左多巴; High-performance liquid chromatography; Parkinsonism; Plasma levodopa; |
語 文 | 英文(English) |
中文摘要 | 左多巴是治療巴金森氏病最有效的藥物,但是長期接受左多巴治療的患 者卻常出現藥效波動及異動症等嚴重的併發症。目前許多研究結果顯示左多巴的 藥物動力學對引起這些併發症具有關鍵性的角色,而監測血中左多巴的濃度與臨 床上藥效的變化則可以幫助我們進一步瞭解並處理這些併發症。本研究報告首先 介紹本實驗室運用鋁萃取法及高解析液態色層分析法對血中左多巴濃度的定量 分析,進一步針對七位具有藥效波動症的巴金森氏病患進行血中左多巴濃度的測 定及臨床藥效的同步監測。其中三位病患出現“wearing-off phenomenon”,他們 臨床上的表現和血中左多巴濃度的變化相吻合。另外四位具有複雜藥效波動的患 者,臨床上的症狀亦呈現與左多巴血中濃度相當程度的相關。我們根據監測的結 果進一步調整這四位病患的藥物劑量及給藥方式以改善藥物動力學後,藥效反應 都有了明顯的進步。這些結果顯示同步監測血中左多巴濃度及臨床藥效對於部份 具有藥效波動症的病患在治療上確實有良好的助益。 |
英文摘要 | Motor fluctuations and abnormal involuntary movements are common complications encountered in advanced Parkinson�s disease (PD) patients with long-term levodopa therapy. Monitoring of plasma levodopa concentrations and clinical effects has been reported to benefit the management of these complications. However, to our knowledge, there is no data available in Taiwan concerning the correlation between the plasma levodopa levels and motor fluctuations. In this study, we developed the laboratory methodology for plasma levodopa determination by using the aluminum extraction procedure and HPLC-ED. Serial blood samples and motor scores were obtained from 7 PD patients, and the correlation between plasma levodopa levels and motor responses were studied individually. In three patients with wearing-off phenomenon, plasma levodopa concentrations are compatible with the clinical "n"and"off" states. In the other four patients with complex fluctuating responses, their levodopa dosages were adjusted by the results of monitoring. Better motor responses were achieved by optimization of the levodopa pharmacokinetics in these patients. Our preliminary data suggest that simultaneous monitoring of plasma levodopa concentrations and clinical effects might be helpful to improve the therapeutic strategy in some of the parkinsonian patients with fluctuating responses to levodopa. |
本系統中英文摘要資訊取自各篇刊載內容。