頁籤選單縮合
題名 | Synthesis, Anti-allergic and Anti-inflammatory Activities of N-Substituted Benzyl-6 (or 7)-ethyl-2,3,4,9-tetrahydrofuro[2,3-b]quinolin-3,4-diones= |
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作者 | 張建平; 林宗平; 王繼平; 郭盛助; Chang, Chien-ping; Lin, Tsung-ping; Wang, Jih-pyang; Kuo, Sheng-chu; |
期刊 | 中華藥學雜誌 |
出版日期 | 20011000 |
卷期 | 53:5 2001.10[民90.10] |
頁次 | 頁239-256 |
分類號 | 414.51 |
語文 | eng |
關鍵詞 | Furoquinoline; Anti-allergic activity; Anti-inflammatory activity; |
英文摘要 | A series of N-substituted benzyl-6 (or 7)-ethyl-2,3,4,9-tetrahydrofuro[2,3-b]quinolin-3,4-diones were synthesized. They were evaluated for anti-allergic and anti-inflammatory activities by inhibition of mast cell degranulation, neutrophil degranulation, and superoxide formation in neutrophils. Among them, N-o-fluorobenzyl-6-ethyl-2,3,4,9-tetrahydrofuro[2,3-b]quinolin-3,4-dione (39) significantly inhibited fMLP-induced neutrophil degranulation at high concentrations (30 mM). The structure-activity relationships of these compounds indicated that 6-ethyl substituted derivatives displayed stronger inhibitory activity against the release of b-glucuronidase during fMLP-induced neutrophil degranulation compared to 7-ethyl substituted derivatives. |
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