頁籤選單縮合
題名 | Expression of p53 in Gastric Cardiac Carcinoma with Lymph Node Metastasis=p53在胃賁門癌併淋巴轉移的表現 |
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作者 | 許南榮; 陳維仁; 林正琴; 周逢復; 李鴻森; Hsu, Nan-yung; Chen, Wei-jen; Lin, Cheng-ching; Chou, Fong-fu; Lee, Hong-shen; |
期刊 | 中臺灣醫學科學雜誌 |
出版日期 | 19990300 |
卷期 | 4:1 1999.03[民88.03] |
頁次 | 頁22-28 |
分類號 | 416.243 |
語文 | eng |
關鍵詞 | 胃賁門癌; p53; Gastric cardiac carcinoma; |
中文摘要 | 本研究計劃在於探測p53在胃賁門癌併有漿膜侵犯和局部淋巴腺轉移時的表現。實驗方法在於採取免疫組織化學研究,針對30例原發性胃癌組織包括胃癌組織、正常胃組織以及441個切除之淋巴腺之臘塊標本,分析p53的表現。結果發現30例中有12例(40%)呈p53陽性反應。而在p53表現的陽性和陰性分組中,比較以下各臨床病理因素包括年齡、性別、腫瘤大小、Borrmann型態、分化、淋巴血管轉移、淋巴腺轉移和食道侵犯,皆無顯著性差異。在441個切除之淋巴腺中,有189個淋巴腺轉移,包括22例為T3N1,2例為T3N2,皆可進行p53之探測。此24例中有7例(29.2%)呈p53陽性反應。在追蹤期間有76.7%(23/30)在手術後2年死亡。在30病例中,原發生胃癌組織p53陽性反應和陰性反應平均存活時間分別為213個月和25.9個月(p值=0.647)。而22例T3N1病例中,在轉移淋巴組織有p53陽性反應者平均存活時間為8.9個月,比p53陰性反應者平均存活時間33個月還差(p=0.029)。本研究雖然病例僅30例,由初步研究結果發現p53在轉移淋巴腺的表現,對於胃賁門癌併漿膜侵犯病例之預後有關鍵性影響。 |
英文摘要 | The aim of this study is to examine whether the expression of p53 can be a prognostic factor in cardiac carcinoma of the stomach and metastatic lesions of regional lymph nodes. Immunohistochemical study of p53 was performed on formalin-fixed, paraffin-embedded tissue sections of 30 primary carcinomas of the stomach and 441 regional lymph nodes of our sample of 30 patients. Of 30 primary gastric cardiac carcinoma, 12 cases (40%) had positive staining for p53. No correlation was observed between p53-positive and p53-negative cases in the various clinicopathological factors, including age, gender, tumor size, Borrmann type, histological differentiation, lymphovascular invasion, lymph node metastasis, or esophageal invasion. One hundred and eighty-nine metastatic lesions from 441 lymph nodes were disclosed in 24 patients. Twenty-two cases were T3N1 and two cases were T3N2. p53 oncoprotein was positive in seven metastatic cases (29.2%). During the follow-up period, 23 patients (76.7%) died within two years after surgery. The median survival rate of p53-positive and p53-negative cases in the primary tumors was 21.3 months and 25.9 months, respectively (p=0.647). Among the 22 patients with T3N1, the median survival rate of the patients who were p53-positive in the metastatic lymph nodes was 8.9 months, significantly lower than that of the patients who were p53-negative (33.0 months, p=0.029). Our findings suggest that the expression of p53 in the metastatic lesions of lymph nodes may be a prognostic factor in gastric cardiac carcinoma. |
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