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題名 | A Virilizing Ovarian Tumor in a Postmenopausal Woman=停經後婦女罹患雄性化卵巢瘤病例報告 |
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作者 | 李信堂; 劉嘉燿; 李恆昇; 吳篤安; Lee, Seing-tom; Liu, Jah-yao; Lee, Herng-sheng; Wu, Du-an; |
期刊 | 醫學研究 |
出版日期 | 19970900 |
卷期 | 18:2 1997.09[民86.09] |
頁次 | 頁108-114 |
分類號 | 417.25 |
語文 | eng |
關鍵詞 | 雄性化卵巢瘤; 停經後婦女; 雄性化; 萊狄氏細胞瘤; Virilizing tumor; Postmenopausal woman; Virilization; Leydig cell tumor; |
中文摘要 | 卵巢腫瘤引起停經婦女產生多毛症或雄性化的現象相當罕見,因此 特別提出來報告。 這是一個70歲停經婦女,主訴漸進性額頂禿髮及面部鬍鬚增生約5個月之 久。過去病史方面,6年前發現糖尿病,以口服降血糖藥及飲食控制。月經及 生產史正常,無雄性化或多毛症家族史。理學檢查除禿髮和面部多毛外,無異 常發現。經陰道超音波檢查,發現在側卵巢較大(24*26*29mm),併一2公分大 小的結節。腹腔鏡檢因骨盆沾黏而視野不佳。腎上腺斷層掃描正常。血漿睪固 酮高(12.1ng/ml)而DHEA-S (dehydroepiandrosterone sulfate, androstenedion及17-OHp (17-hydroxyprogesterone)均正常。因為腎上腺斷 層掃描,血漿DHEA-S和dexamethasone抑制試驗正常再加上陰道超音波的發現, 所以認為過高的雄性素來自卵巢。剖腹切除子宮及卵巢,經病理檢查證實為左 側卵巢萊狄氏細胞瘤。手術後血漿睪固酮即降至正常值(0.1ng/ml),而病人狀 況良好於術後2週出院。 |
英文摘要 | Androgen-producing ovarian tumors are a relatively uncommon but serious cause of virilization in postmenopausal women. We present the case of a 70-year-old woman referred for evaluation of virilization which developed over 5 months. Clinical examinations and investigations suggested that the source of androgen excess was ovarian origin. An ovarian tumor was confirmed (Leydig cell tumor) and removed at laparotomy. The serum androgen level returned to normal soon postoperatively. It is emphasized here that evidence of virilization is a key feature that requires investigation. |
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