查詢結果分析
來源資料
相關文獻
- Mechanisms and Clinical Relevance of Androgens and Androgen Receptor Actions
- 性荷爾蒙受體之生理調控及疾病
- Expression of Androgen, Estrogen and Progesterone Receptors in Mucinous Carcinoma of the Breast
- 同化類固醇對肌力的影響
- Changes in Serum Prostate-Specific Antigen After Orchiectomy and Complete Androgen Blockade in Patients with Stage D Prostatic Carcinoma
- Coronary Heart Disease Caused by Hormonal Therapy is Determined by Overall Profile of HDL, Apo A-Ⅰ, and Apo A-Ⅱ, not by VLDL, Which in Turn is Mediated by Transactivation and Transcription of Nuclear Receptor
- 多不飽和脂肪酸調控脂質代謝基因表達之機制
- Effect of Factors on the Quantification of Androgen Receptors of Rat Prostate
- Association between Bullying Involvement and Body Weight Status among Adolescents in Southern Taiwan
- Male and Female Sexual Behaviors in Normal and Prenatally Androgenized Female Hamsters
頁籤選單縮合
題名 | Mechanisms and Clinical Relevance of Androgens and Androgen Receptor Actions=雄性激素與雄性激素受體作用之機轉與臨床相關性 |
---|---|
作者姓名(中文) | 康宏佑; 蔡孟穎; 張傳祥; 黃國恩; | 書刊名 | 長庚醫學 |
卷期 | 26:6 2003.06[民92.06] |
頁次 | 頁388-402 |
分類號 | 415.8 |
關鍵詞 | 雄性激素; 雄性激素受體; 調節因子; Androgen; Androgen receptor; Co-regulators; |
語文 | 英文(English) |
中文摘要 | 雄性激素,泛指睪固酮及5α-雙氫化睪固酮,影響在許多標的周圍組織並且具有多種作用,其作用經由與雄性激素受體的結合達到其生物功能。雄性激素受體為類固醇受體家族成員之一,表現於眾多的組織器官中,並且隨著組織發育、老化、惡性組織轉變而改變。近年來,由於雄性激素受體輔助因子的發現及研究,促進關於雄性激素受體的生理及病理角色的縱深探討。輔助因子經由調控ligand與DNA與雄性激素受體之間的結合能力,進而達到改變雄性激素受體的活性;而突變或改變調節因子可能是影響雄性激素受體相關疾病進程的原因之一。 然而,儘管在此領域有密集的研究,與雄性激素受體及其調節因子相關臨床研究的疾病,如骨質疏鬆症與雄性激素不反應症仍是許多有趣而未知的問題尚待進一步研究。本篇文章將廣泛的探討雄性激素的基因與非基因調控層面以及其受體與調節因子之間交互作用,同時也將探討雄性激素受體與調節因子在臨床疾病上的分子生物機制。 |
英文摘要 | Androgens, principally testosterone and 5[]-dihydrotestosterone, affect a number of diverse responses in a varioty of peripheral target tissues. Their biological actions are mediated by a ligand-dependent nuclear transcription factor, the androgen receptor(AR). The AR is a member of the steroid hormone receptor family, which is found in a variety of tissues, and changes throughout development, aging, and malignant transformation. Recently, cloning and characterization of several AR co-regulators have allowed for cellular and molecular analysis of many different aspects of androgen physiology and pathophysiology. The transcriptional activity of AR is regulated by AR co-regulators, which influence the ligand selectivity and DNA binding capacity of AR. Aberrant co-regulator function due to mutation or altered expression levels may be a contributing factor in the progression of AR-mediated diseases. However, in spite of the intensity of research activity in this area, many interesting questions regarding the fundamental mechanism of AR and co-regulators on androgen-related diseases, such as osteoporosis and androgen insensitive syndrome remain unsolved. In this review, we provide a brief overview of genomic and non-genomic androgens/AR actions, as well as the regulation of their co-regulators. We also explore several intriguing aspects of ther molecular biology of AR and co-regulators that are related to clinical disease. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。