頁籤選單縮合
題名 | Failure in the Treatment of Long-Standing Osteoporosis in Cerebrotendinous Xanthomatosis=腦及肌腱黃瘤病的長期骨質疏鬆症之治療失敗 |
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作者 | 張文能; 呂鎮中; Chang, Wen-neng; Lui, Chun-chung; |
期刊 | 臺灣醫學會雜誌 |
出版日期 | 19970300 |
卷期 | 96:3 1997.03[民86.03] |
頁次 | 頁225-227 |
分類號 | 415.596 |
語文 | eng |
關鍵詞 | 腦; 肌腱黃瘤病; 骨質疏鬆症; Cerebrotendinous xanthomatosis; Osteoporosis; Bone mineral density; Cholestanol; |
英文摘要 | We evaluated the therapeutic effect of combined therapy with chenodeoxycholic acid, calcium carbonate, and sodium bicarbonate on long-standing osteoporosis in three siblings (two women and one man, aged 30-38 yr) with cerebrotendinous xanthomatosis (CTX). The evaluation was based on the measurement of bone mineral density (BMD) before and after 3 years of combined therapy. Clinically, the therapeutic effect was quite limited (almost no change in BMD values), and did not parallel the marked decrease in serum cholestanol level (normalization of serum levels). While the reason for the therapeutic failure in our patients is not Known, it is possible that delay in starting treatment may have been a factor. Measurement of BMD for evaluation of therapeutic effect in long-standing osteoporosis in CTX patients is of little practical value. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。