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題名 | Synthetic Chemistry and Function of Bacterial Cell Surface Glycoconjugates |
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作者姓名(外文) | Kusumoto,Shoichi; Fukase,Koichi; Oikawa,Masato; Suda,Yasuo; | 書刊名 | Journal of the Chinese Chemical Society |
卷期 | 49:4 2002.08[民91.08] |
頁次 | 頁453-458 |
分類號 | 369.4 |
關鍵詞 | Synthesis; Glycoconjugates; Lipid A; Lipopolysaccharide; Biological activity; Cytokines; Immunostimulation; Innate immunity; |
語文 | 英文(English) |
英文摘要 | Typical bacterial glyeoconjugates are known to stimulate immunological systems of higher animals and thereby play important roles in the primary defense of animals against bacterial infection. Lipopolysaccharide (LPS) of gram-negative bacteria is a representative of such glycoconjugates. LPS was first discovered as a potent bacterial toxin and named endotoxin but was soon found to exhibit irnmunostimulating activity. By the use of our synthetic pure preparations, the lipophilic partial structure of LPS, designated lipid A, proved to be the active entity responsible for both endotoxic and immunostimulating activities of LPS. This paper deals with our recent chemical synthesis and functional study of lipid A and related compounds. Synthesis is described of its various structural analogues, radio-labeled compound and Re-type LPS that contains two additional sugar moieties linked to lipid A. o additional sugar moieties linked to lipid A. |
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