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題 名 | Immunohistochemical Localization of Deleted-In-Colon-Cancer (DCC) Protein in Human Epithelial, Neural, and Neuro-Endocrine Tissues in Paraffin Sections with Antigen Retrieval=以抗原恢復免疫組織化學染色法偵測石蠟標本內人類上皮、神經及神經內分泌組織之DCC蛋白 |
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作 者 | 許永祥; 蕭正光; 鍾正明; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
卷 期 | 17:7 2001.07[民90.07] |
頁 次 | 頁351-357 |
分類號 | 415.13 |
關鍵詞 | 抗原恢復免疫組織化學染色法; 上皮; 神經; 神經內分泌組織; DCC蛋白; DCC基因; 超科免疫球蛋白; DCC; Antigen retrieval; Neuroendocrine; |
語 文 | 英文(English) |
中文摘要 | DCC 基因(Deleted in colon cancer)位於第18對染色體,在大腸直腸癌 病患約有70%發生基因刪除。DCC基因負責製造一個屬於超科免疫球蛋白之蛋 白,此蛋白與N-CAM穿膜蛋白相似,DCC基因是一個推想中之抑癌基因;如 改變此穿膜性蛋白基因(包括N-CAM)之轉錄本,會產生同功蛋白。我們以一種 多株抗DCC基因抗體,用抗原恢復免疫組織化學染色法偵測DCC蛋白,發現 DCC同功蛋白在腸胃道杯狀細胞、食道和皮膚鱗狀上皮及膀胱移形上皮的細胞 質、子宮內膜、子宮內頸、前列腺、膽囊及乳房之腺體或腺管和大腦皮質及小腦 普金吉氏細胞(Purkinje cells)的細胞質表達。 此外,我們發現DCC蛋白亦可在 胃、小腸、蘭尾和大腸之嗜銀細胞、甲狀腺C細胞、腎上腺嗜酪細胞、胰臟蘭 氏小島及交感神經節之神經元的細胞質表達,此種局部分佈表現暗示DCC基因 產物在人類組織的神經內分泌細胞有很豐盛的表達。 |
英文摘要 | A gene called deleted in colon cancer (DCC) has been identified on a region of chromosome 18, which is deleted in 70% of colorectal cancers. The DCC gene encodes a protein belonging to the immunoglobulin superfamily with similarity to the N-CAM transmembrane proteins, and it is a putative tumor-suppressor gene. Alternative splicing of transcripts of transmembrane proteins, including N-CAM, is know to occur, resulting in different isoforms of the protein. Using a polyclonal antibody against the DCC gene product, we have demonstrated, by antigen retrieval immunostaining, the presence of a DCC protein isoform on the cell surface of goblet cells in the G-I tract, cytoplasm of squamous epithelium in the skin & esophagus and transitional epithelium in the urinary bladder, ductal glandular epithelium of endometrium, endocervix, prostate, gall bladder and breast, cytoplasm of neuron in the cerebral cortex and Purkinje cells in the cerebellum. In addition, we also demonstrated DCC protein expression in neuroendocrine cells including argentaffin cells of the stomach, small intestine, appendix and colon, C cells of the thyroid gland, chromaffin cells of the adrenal gland, islets of Langerhans in the prancreas and neurons of the sympathetic ganglion. This restrictive distribution suggests the DCC gene products may be abundant expression in neuroendocrine cells of human tissue. |
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