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頁籤選單縮合
題名 | Methicillin抗藥性金黃色葡萄球菌菌血症的臨床表現與微生物學特徵:48個個案分析=Clinical Manifestations and Microbiological Characteristics of Methicillin-resistant Staphylococcus aureus in Bacteremic Patients: Analysis of Forty Eight Cases |
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作者 | 陳昶華; 林麗珍; 廖淑真; 陳昱旻; 張玉君; 劉尊榮; 楊祖光; | 書刊名 | 彰化醫學 |
卷期 | 7:3 2002.07[民91.07] |
頁次 | 頁147-153 |
分類號 | 415.15 |
關鍵詞 | 菌血症; Methicillin抗藥性金黃色葡萄球菌; 萬古黴素抗藥性金黃色葡萄球菌; Bacteremia; Methicillin-resistant Staphylococcus aureus; Vancomycin-resistant Staphylococcus aureus; |
語文 | 中文(Chinese) |
中文摘要 | 背景及目的:觀察Methicillin抗藥性金黃色葡萄球菌菌血症病患的臨床表現, 與篩檢萬古黴素抗藥性金黃色葡萄球菌。 方法: 自民國 88 年 7 月 1 日至民國 89 年 6 月 30 日止, 針對彰化基督教醫院 Methicillin 抗藥性金黃色葡萄球菌 (methicillin-resistant Staphylococcus aureus) 菌血症的病患進行前瞻性的研究,分析 病患的臨床表現,並且進行萬古黴素抗藥性金黃色葡萄球菌的篩檢。 以 Pearson X �斯必� 計方法分析。 結果:在 48 位病患,男性 20 位,女性 28 位。年齡分布於 2 歲與 87 歲 之間, 平均年齡為 63.2 歲 (63.2 ± 22.3),發現 MRSA 菌血症在本院的發生率為十萬分 之 92 人次。MRSA 菌血症死亡率為 37.5%(18/48)。MRSA 菌落大小 (P=0.61)、紙錠擴散試 驗的抑菌環直徑 (P=0.83)、及 E-test 萬古黴素最低仰菌濃度 (P=1.0), 與臨床預後並無 明顯的統計相關性。 結論:目前本院沒有萬古黴素抗藥性金黃色葡萄球菌。MRSA 菌血症個 案的嚴重性是值得重視的。 |
英文摘要 | Background and purpose: We focused on the analysis of patients afflicted with methicillin-resistant Staphylococcus aureus (MRSA). We examined clinical presentations in these patients and the microbiological characteristics of Staphylococcus aureus isolates. In addition, we screened specimens for the presence of vancomycin-rsistant Staphylococcus aureus. Methods:We studied a cohort of 48 MRSA bacteremic patients seen at CCH during the period from July 1, 1999 to tel-Haenszel's test and Fisher's exact test for statistical analysis. Results:Forty-eight patients were analyzed. Twenty patients were male, and 28 were female. Female to male ratio was 1.4. The mean age was 63.2 years. The incidence of MRSA bacteremia was 0.092%. The mortality rate was 37.5% (18/48). We reexamined MRSA strains by methods as suggested by NCCLS, and found that the clinical outcome falis to correlate with the colony size (P=0.61), the size of inhibition zone (P=0.83), and the E-test results (P=1.0). We did not identify any vancomycin-resistant Staphylococcus aureus strains during this period. Conclusion:As we failed to identify any vancomycin-resistant Staphylococcus aureus strains, it is logic for us to focus only on problems in patients who were bacteremic with methicillin-resistant Staphylococcus aureus in future studies. |
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