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題名 | 1,5-雙取代四唑雜環衍生物的合成研究=Syntheses of 1,5-Disubstituted Tetrazole Derivatives |
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作者 | 施美秀; Shih, Mei-hsiu; |
期刊 | 南臺科技大學學報 |
出版日期 | 20020300 |
卷期 | 26 2002.03[民91.03] |
頁次 | 頁79-87 |
分類號 | 346.2 |
語文 | chi |
關鍵詞 | 四唑化合物; 甲醯疊氮肟化合物; 雪梨酮; Tetrazoles; Azidoximes; Sydnones; |
中文摘要 | 四唑化合物是一種應用廣泛的雜環化合物,隨著取代基的不同而行不同的生理性質及功能,叉因雪梨酮常具有藥理作用,故本文致力於開發4-四唑雜環基雪梨酮衍生物的合成。首先經由3-芳香基雪梨酮-4-甲醯氯和疊氮化鈉作用,生成相對應的雪梨酮-4-甲醯疊氦□,而非環狀的1-羥基-5-雪梨酮基四唑化合物,欲製備環狀的四唑化合物,必須先利用氯化乙醯使其環化,再於熱酒精中進行去乙醯化反應,而製得預期的四唑雜環化合物。 |
英文摘要 | Various substituted tetrazoles have biological properties and behavior. Such heterocyclic compounds are extensively applied in many fields. Meanwhile, sydnone compounds are well known to exhibit biological and pharmacological activities, it is interesting to focus on the syntheses of 4-tctrazoic substituted sydnones. In this study, 3-arylsydnone-4-carbohydroximic acid chlorides were employed to react with sodium azide to give the corresponding sydnone-4-car bazidoximes, but not 1-hydroxy-tetrazoles. To obtain the desired tetrazoles, the azidoximes should first cyclize with acetyl chlorides to afford the acctyl derivatives. The cyclized tetrazole derivatives underwent deacylation upon heating in ethanol to give the desircd tetrazole products. |
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